Cellular Membrane MCDB108 A

Question 1

_______ _______ are fluid mosaics of lipids, proteins, and glycoconjugates.

Answer 1

cellular membranes

Question 2

cells contain ______ membranes with distinct compositions

Answer 2

internal

Question 3

glycerophospholipids are made in the _____ and distributed to other organelles.

Answer 3

ER

Question 4

membrane _____ control permeability and signaling at membranes.

Answer 4

proteins

Question 5

the fluid mosaic model says cellular membranes are a complex and dynamic arrangement of _____ and ______.

Answer 5

proteins, lipids

Question 6

there is rapid ______ ______ in the phospholipid bilayer.

Answer 6

lateral diffusion

Question 7

lipid ____ are non random discrete assemblies of lipids and proteins found on the plasma membrane

Answer 7

rafts

Question 8

lipid rafts arise through _______ association of certain types of lipids and proteins.

Answer 8

preferential

Question 9

asymmetry between leaflets is regulated by _______ : flippases and scramblases

Answer 9

enzymes

Question 10

the lipid _________ of each organelle is _________

Answer 10

composition, distinct

Question 11

phospholipids are made in the ______ leaflet of the ER and distributed to other organelles

Answer 11

cytosolic

Question 12

how are lipids distributed to other organelles?

Answer 12

vesicular trafficking, lipid carrier proteins, membrane contact sites

Question 13

membrane proteins can be _______ or ______

Answer 13

peripheral, integral

Question 14

proteins can be linked to membranes by ____ ____ anchors.

Answer 14

covalent lipid

Question 15

membrane proteins adopt typical ________ structure

Answer 15

secondary

Question 16

transmembrane domains can be predicted by ________

Answer 16

hydrophobicity

Question 17

proteins are made on _______ ribosomes and targeted to membranes by targeting signals

Answer 17

cytosolic

Question 18

______ can bend, shape, and fuse membranes and signal across membranes.

Answer 18

proteins

Question 19

proteins mediate the _____ of most molecules across membranes

Answer 19

transport

Question 20

_____ membrane proteins completely cross the lipid membrane

Answer 20

integral

Question 21

_______ membrane proteins are bound to integral proteins

Answer 21

peripheral

Question 22

integral membrane proteins span the membrane in _______ and _________

Answer 22

alpha helices, beta barrels

Question 23

the cytosol is a _______ environment when the extracellular space is _________

Answer 23

reducing, oxidizing

Question 24

a lipid membrane is _____ A.

Answer 24

30

Question 25

transmembrane _________ can be identified on the basis of their _________. look for a peak above ____ of atleast _____ residues

Answer 25

alpha helices, hydrophobicity, 1.5, 20

Question 26

transmembrane _______ have alternating hydrophobic and hydrophillic residues and are ____ to cross the membrane

Answer 26

beta barrels, 7-9

Question 27

______ can be covalently attached to lipid _______-

Answer 27

proteins, anchors

Question 28

proteins in the ____ can be attached to GPI anchored protein

Answer 28

ER

Question 29

proteins in the _____ can be linked to fatty acid anchors through N terminus or cysteines

Answer 29

cytosol

Question 30

integral membrane proteins can be solubilized using ______

Answer 30

detergents

Question 31

peripheral membrane proteins are removed by ____ or _________

Answer 31

pH, salt wash

Question 32

membrane proteins take part in membrane _____, ____ and ______ and ______

Answer 32

restructuring, sensing and signaling, transport

Question 33

______ allow charged molecules to cross the membrane

Answer 33

transporter proteins