Glyceryl Trinitrate Flashcards
GTN - Drug Class/Presentation
Vasodilator, Spray - 400mcg/dose
GTN - Pharmacology
GTN is a potent vasodilator that decreases preload by increasing venous capacity, pooling venous blood in the peripheral veins, reducing ventricular filling pressure and decreasing arterial pressure. Because of this cascade it also causes vasodilation in the coronary arteries that are in spasm and may assist the redistribution of blood flow along the collateral channels in the heart
GTN - Metabolism
GTN is readily absorbed and metabolised by the liver
GTN - Onset, Duration, Half-life
Onset -
GTN - Indications
- Suspected ACS (with pain)
- Acute cardiogenic pulmonary oedema
- Autonomic dysreflexia (BP greater than 160mmHg)
- Irukandji syndrom (BP greater than 160mmHg)
GTN - Contraindications
- KSAR or hypersensitivity to GTN
- Heart rate 150
- Systolic BP less than 100mmHg
- Acute CVA
- Head Trauma
- Phosphodiesterase inhibitor in the past 24hrs
GTN - Precautions
- Suspected inferior AMI
- Cerebral vascular disease
- Risk of hypotension and/or syncope
- Intoxication
- Phosphodiesterase inhibitor in the past 4 days
GTN - Side Effects
- Dizziness
- Hypotension
- Syncope
- Reflex tachycardia
- Vascular headaches
GTN - Route of Administration
SUBLING
GTN - Suspected ACS Adult Doses
400mcg repeated at 5 mins, no max dose
GTN - APO (cardiogenic) Adult Doses
400mcg, repeated at 5 mins, no max dose
GTN - Autonomic dysreflexia and Irukandji syndrome (BP greater than 160mmHg) Adult Doses
400mcg, repeated at 5 mins, no max dose
GTN - Autonomic dysreflexia and Irukandji syndrome (BP greater than 160mmHg) Paediatric Doses
QAS consult line required
