Ceftriaxone

Question 1

Ceftriaxone - Drug Class/Presentation

Answer 1

Antibiotic, 1g (Powder)

Question 2

Ceftriaxone - Pharmacology

Answer 2

Ceftriaxone is a third generation cephalosporin antibiotic with a baterialcidal action

Question 3

Ceftriaxone - Metabolism

Answer 3

Excreted as a variety of active and inactive metabolites from the body through urine, bile and faeces

Question 4

Ceftriaxone - Indications

Answer 4

Suspected meningococcal septicaemia (with a non-blanching petechial AND/OR purpuric rash

Question 5

Ceftriaxone - Contraindications

Answer 5

• KSAR or hypersensitivity to cephalosporin drugs

- Known anaphylaxis or severe allergy to penicillin based drugs

Question 6

Ceftriaxone - Precautions

Answer 6

• Nil

Question 7

Ceftriaxone - Side effects

Answer 7

• Nausea AND/OR vomiting

- Pain at the site of IM injection

Question 8

Ceftriaxone - Onset, Duration, Half-life

Answer 8

Onset - Variable
Duration - 1 day
Half-life - 5.8-8.7 hrs

Question 9

Ceftriaxone - Routes of administration

Answer 9

• IM
• IV
• IO

Question 10

Ceftriaxone - Adult doses

Answer 10

IM - 1g (mix with 3.6mL water for injection)

IV - 1 g (mix with 9.6mL water for injection)

Question 11

Ceftriaxone - Paed doses

Answer 11

50mg/kg rounded to the nearest 5kg