Clopidogrel

Question 1

Clopidogrel - Drug class/Presentation

Answer 1

Anti-platelet, 75mg tablet

Question 2

Clopidogrel - Pharmacology

Answer 2

Clopidogrel is a specific and potent platelet aggregation inhibitor. It selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor, thereby inhibit platelet aggregation

Question 3

Clopidogrel - Metabolism

Answer 3

Hepatic metabolism with near equal amounts excreted in the urine and faeces

Question 4

Clopidogrel - Indications

Answer 4

Patients with STEMI who have been selected for pPCI or who have received fibrinolytic therapy

Question 5

Clopidogrel - Contraindications

Answer 5

• KSAR or hypersensitivity to Clopidogrel
• Patients contraindicated for prehospital fibrinolysis
• Current Clopidogrel or Ticagrelor therapy
• Patients

Question 6

Clopidogrel - Precautions

Answer 6

• Severe renal impairment

Question 7

Clopidogrel - Side effects

Answer 7

Haemorrhage

Question 8

Clopidogrel - Onset, Duration, Half-life

Answer 8

Onset - 30 mins
Duration - 7-10 days
Half-life - 8hrs

Question 9

Clopidogrel - Adult doses

Answer 9

STEMI for pPCI - 600mg PO

STEMI for tPA - 300mg PO