Atropine Flashcards
Atropine - Drug Class and Presentation
Anticholinergic (antimuscarinic), 1.2mg/1mL
Atropine - Pharmacology
Atropine works by inhibiting the action of the parasympathetic nervous system allow for an unchallenged sympathetic response. It successfully blocks the action of the vagus nerve on the heart, increases the rate of the SA node, conduction through the AV node and blocks exocrine gland activity
Atropine - Metabolism
Atropine is metabolised by the liver and excreted daily by the kidneys
Atropine - Indications
- Bradycardia (with poor perfusion)
- Envenomation (with increased parasympathetic activity)
- Hypersalivation (secondary to Ketamine administration)
- Organophosphate toxicity (with cardiac AND/OR respiratory compromise)
Atropine - Contraindications
KSAR or hypersensitivity to Atropine
Atropine - Precautions
- Atrial Flutter
- Atrial Fibrillation
- AMI
- Glaucoma
Atropine - Side Effects
- Agitation
- Hallucinations
- Dilated Pupils
- Dry mouth, skin, reduced bronchial and gastric secretions
- Tachycardia
Atropine - Onset, duration, halflife
Onset - 1-2 min (peak 15-50 min)
Duration - up to 5 hrs
Half Life - 3-4 hrs
Atropine - Routes of Administration
- IM
- IV
- IO
Atropine - Bradycardia Adult Dose
600mcg, repeat once at 2 min
Atropine - Envenomation Adult Dose
1.2mg, repeat at 5 mins, no max
Atropine - Hypersalivation Adult Dose
600mcg, once only
Atropine - Organophosphate toxicity Adult Dose
1.2mg, repeat at 5 mins, no max
Atropine - Bradycardia Paed Dose
20mcg/kg, repeat once at 2 min
Atropine - Envenomation Paed Dose
20mcg/kg, repeated at 5 min, no max dose
