Amiodarone Flashcards
Amiodarone - Class & Presentation
Anti-arrhythmic, 150mg/3mL
Amiodarone - Pharmacology
Amiodarone prolongs the duration of the action potential and therefore the refractory period of the atrial, nodal and ventricular tissues. IT also reduces conduction across all cardiac tissue - including myocardial and conducting system cells. Amiodarone demonstrates electrophysiological properties across all Vaughan-Williams Class groups, which enables a broad spectrum of activity.
Amiodarone - Metabolism
The majority of amiodarone is excreted by the liver and GI tract by billiary exretion, there may be some hepatic recirculation.
Amiodarone - Indications
- Cardiac arrest - Refractory VF/pulseless VT
- Sustained conscious VT - Stable
Amiodarone - Contraindications
Cardiac Arrest: - Nil Sustained conscious VT: - KSAR or hypersensitivity to amiodarone - severe conduction disorders without pacemaker or AICD in situ - current amiodarone therapy - concurrent anti-arrhythmic therapy that prolongs the QT interval - pregnancy or lactation
Amiodarone - Precautions
Cardiac Arrest: - concurrent anti-arrhthmic therapy that prolongs the QT interval - thyroid disease Sustained conscious VT: - hypotension - thyroid disease
Amiodarone - Side Effects
- Hypotension
- Bradycardia
- Nausea and/or Vomiting
- Peripheral paraesthesia
Amiodarone - Onset, Duration & Half-life
Onset - 5 min
Duration - 30 min
Half-Life - 14-110 days (with chronic dosing)
Amiodarone - Routes of Administration
- IV
- IO
- INF
Amiodarone - Cardiac Arrest Doses (Adult)
IV - 300mg, slow push over 2 min, repeat at 150mg after 5 min
IO - 300mg, slow push over 2 min, repeat at 150mg after 5 min
Amiodarone - Sustained conscious VT Doses (Adult)
INF - 300mg over 30 min, single dose only
Amiodarone - Cardiac Arrest Doses (Paed)
IV - 5mg/kg, slow push over 2 min, single dose only
IO - 5mg/kg, slow push over 2 min, single dose only
