Enoxaparin

Question 1

Enoxaparin - Drug class/Presentation

Answer 1

Anticoagulant, 40mg/0.4mL and 100mg/1mL

Question 2

Enoxaparin - Pharmacology

Answer 2

Enoxaparin has several actions on the coagulation pathway through its binding to antithrombin III. The antithrombotic activity is related to inhibition of thrombin generation and inhibition of two key coagulation factors: factor Xa and thrombin

Question 3

Enoxaparin - Metabolism

Answer 3

Hepatic, but mostly eliminated unchanged

Question 4

Enoxaparin - Indications

Answer 4

Patients with STEM who will receive tPA

Question 5

Enoxaparin - Contraindications

Answer 5

• KSAR or hypersensitivity to Enoxaparin or Heparin

- Patients contraindicated for prehospital tPA

Question 6

Enoxaparin - Precautions

Answer 6

• Renal/hepatic impairment

- Low body weight (

Question 7

Enoxapain - Side effects

Answer 7

• Haemorrhage

- Thrombocytopenia

Question 8

Enoxaparin - Onset, Duration, Half-life

Answer 8

Onset - Immediate
Duration - 12-24 hrs
Half-life - 4.4 hrs for 40mg dose

Question 9

Enoxaparin - Routes of administration

Answer 9

• SUBCUT

- IV

Question 10

Enoxaparin - Adult doses

Answer 10

• loading dose of 30mg IV

- maintenance dose 1mg/kg SUBCUT