Adrenaline Flashcards
Adrenaline - Class & Presentation
Sympathomimetic, 1mg/1mL OR 1mg/10mL
Adrenaline Pharmacology
Adrenaline is a naturally occurring catecholamine which primarily acts on Alpha and Beta adrenergic receptors. The actions of these receptors cause an increase in heart rate (B1), increase in the force of myocardial contraction (B1), increase in the irritability of the ventricles (B1), bronchodilation (B2) and peripheral vasoconstriction (A1).
Adrenaline - Metabolism
Majority of circulating adrenaline is metabolised by sympathetic nerve endings - breakdown my monoamine oxidase
Adrenaline - Indications
- Anaphylaxis OR Severe allergic reaction
- Sever life-threatening bronchospasm or silent chest
- Bradycardia with poor perfusion
- Cardiac arrest
- Croup
- Shock unresponsive to adequate fluid resuscitation
Adrenaline - Contraindications
Nil
Adrenaline - Precautions
- Hypertension
- Hypovolaemic shock
- Concurrent MAOI therapy
- Multiple sclerosis
Adrenaline - Side Effects
- Anxiety
- Hypertension
- Palpitations/tachyarrhythmias
- Pupil dilation
- Tremor
Adrenaline - Onset, Duration & Half-life
Onset - 30s IV, 60s IM
Duration - 5-10 min
Half-life - 2 min
Adrenaline - Routes of Administration
- NEB
- IM
- IV
- IO
Adrenaline - Anaphylaxis Doses (Adult)
IM - 300mcg, repeated at 5 min, no max
NEB - 5mg, once only
IV - 20-50mcg, repeat at 1 min, no max
IO - 20-50mcg, repeat at 1min, no max
Adrenaline - Bronchospasm Doses (Adult)
IM - 300mcg, repeat at 5 min, no max
IV - 20-50mcg, repeat at 1 min, no max
IO - 20-50mcg, repeat at 1min, no max
Adrenaline - Bradycardia Doses (Adult)
IV - 20-50mcg, repeat at 1 min, no max
IO - 20-50mcg, repeat at 1min, no max
Adrenaline - Shock Doses (Adult)
IV - 20-50mcg, repeat at 1 min, no max
IO - 20-50mcg, repeat at 1min, no max
Adrenaline - Cardiac Arrest Doses (Adult)
IV - 1mg, repeat every 3-5 min, no max
IO - 1mg, repeat every 3-5 min, no max
