Aspirin

Question 1

Aspirin - Class & Presentation

Answer 1

Antiplatelet, 300mg tablet

Question 2

Aspirin - Pharmacology

Answer 2

Aspirin inhibits platelet aggregation by irreversibly inhibiting COX, reducing the synthesis of Thromboxane A2 for the life of the platelet. This action forms the basis of preventing platelets from aggregating to exposed collagen fibres at the site of vascular injury.

Question 3

Aspirin - Metabolism

Answer 3

Converted to salicylic acid in many tissues, but primarily in the GI mucosa and liver. Subsequently excreted by the kidneys

Question 4

Aspirin - Indications

Answer 4

• Suspected ACS

- Acute cardiogenic pulmonary oedema

Question 5

Aspirin - Contraindications

Answer 5

• KSAR to aspirin or other NSAIDs
• Chest pain associated with psychostimulant OD
• Bleeding or clotting disorders
• Current GI bleeding or peptic ulcers
• Patients

Question 6

Aspirin - Precautions

Answer 6

• Possible aortic aneurysm or other condition that may require surgery
• Pregnancy
• History of GI bleeding of peptic ulcers
• Concurrent anticoagulant therapy

Question 7

Aspirin - Side Effects

Answer 7

• Epigastric pain/discomfort
• Nausea and/or Vomiting
• Gastritis
• GI bleeding
• NSAID induced bronchospasm

Question 8

Aspirin - Onset, Duration & Half-life

Answer 8

Onset - approx 10 min
Duration - approx 1 week
Half-life - 3.2 hrs

Question 9

Aspirin - Routes of Administration

Answer 9

• PO

Question 10

Aspirin - Doses

Answer 10

• 300mg, followed by a small sip of water