Glucocorticoids Flashcards
1
Q
What drugs belong to the glucocorticoids class?
A
Hydrocortisone, prednisone, triamcinolone, dexamethasone, beclomethasone (p.306)
2
Q
What is the mechanism of action of glucocorticoid drugs?
A
Decreased production of leukotrienes and prostaglandins by inhibiting phospholipase A2 and expression of COX-2 (p.306)
3
Q
What are the clinical uses for glucocorticoid drugs?
A
Addison’s disease, inflammation, immunosuppression, asthma (p.306)
4
Q
What are the toxicities associated with glucocorticoid use?
A
Iatrogenic Cushing’s syndrome, diabetes (if use is chronic), adrenal insufficiency when drug is stopped abruptly after chronic use (p.306)
