Diabetes Drugs II Flashcards
What are the toxicites associated with metformin?
GI upset, lactic acidosis (p.305)
When is metformin contraindicated?
In renal failure (lactic acidosis) (p.305)
Name the first generation sulfonylureas.
Tolbutamide, Chlorpropamide (p.305)
Name the second generation sulfonureas.
Glyburide, Glimepiride, Glipizide (p.305)
What is the mechanism of action of sulfonylurea drugs?
Closes K+ channels in beta cell membranes to depolarize beta cells. This triggers insulin release via increased calcium influx (p.305)
What is the clinical use for sulfonylurea drugs?
To stimulate release of endogenous insulin in Type II DM (p.305)
Are sulfonylureas helpful adjunctive therapy in Type I DM?
No- they require some islet function to be effective (p.305)
What toxicities are associated with first generation sulfonylurea drugs?
Disulfiram like effects (p.305)
What toxicities are associated with second generation sulfonylurea drugs?
Hypocalcemia (p.305)
Name the Glitazone/thiazolidinedione drugs.
Pioglitazone, Rosiglitazone (p.305)
To which drug class does Pioglitazone belong?
Glitazone/thiazolidinedione (p.305)
To which drug class does Rosiglitazone belong?
Glitazone/thiazolidinedione (p.305)
What is the mechanism of action of Glitazone/thiazolidinedione drugs?
Increase insulin sensitivity in peripheral tissue by binding to PPAR-y nuclear transcription regulators (p.305)
What is the function of PPAR-y receptors on genes?
Regulation of fatty acid storage and glucose metabolism (p.305)
What is the result of PPAR-y receptor activation?
Increased insulin sensitivity and incerased levels of adiponectin (p.305)