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Endocrinology > Endocrine Pharmacology (all) III > Flashcards

Endocrine Pharmacology (all) III Flashcards

1
Q

What are the toxicites associated with amylin analogues?

A

Hypoglycemia, nausea, diarrhea (p.305)

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2
Q

What drugs are in the GLP-1 analogue class?

A

Exenatide, Liraglutide (p.305)

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3
Q

To which drug class does exenatide belong?

A

GLP-1 analogues (p.305)

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4
Q

To which drug class does liraglutide belong?

A

GLP-1 analogues (p.305)

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5
Q

What is the mechanism of action of GLP-1 analogues?

A

Increases insulin and decreases glucagon release (p.305)

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6
Q

What is the clinical use for GLP-1 analogues?

A

Type II DM (p.305)

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7
Q

What are the toxicities associated with GLP-1 analogues?

A

Nausea, vomiting, pancreatitis (p.305)

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8
Q

What drugs belong to the DPP-4 Inhibitors class?

A

Linagliptin, Saxagliptin, Sitagliptin (p.305)

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9
Q

To which drug class does linagliptin belong?

A

DPP-4 Inhibitors (p.305)

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10
Q

To which drug class does saxagliptin belong?

A

DPP-4 Inhibitors (p.305)

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11
Q

To which drug class does sitagliptin belong?

A

DPP-4 Inhibitors (p.305)

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12
Q

What is the mechanism of action of DPP-4 drugs?

A

Increases insulin and decreases glucagon release (p.305)

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13
Q

What is the clinical use for DPP-4 drugs?

A

Type II DM (p.305)

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14
Q

What are the toxicities associated with DPP-4 drugs?

A

Mild urinary or respiratory infections (p.305)

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15
Q

What is the mechanism of action of propylthiouracil?

A

Blocks peroxidase, thereby inhibiting organification of iodide and coupline of thyroid hormone synthesis. It also blocks 5’deiodinase which decreases peripheral conversion of T3 to T4 (p.306)

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16
Q

What is the mechanism of action of methimazole?

A

Blocks peroxidase, thereby inhibiting organification of iodide and coupline of thyroid hormone synthesis. (p.306)

17
Q

What is the clinical use for propylthiouracil?

A

Hyperthyroidism (p.306)

18
Q

What is the clinical use for methimazole?

A

Hyperthyroidism (p.306)

19
Q

What are the toxicities associated with propylthiouracil?

A

Skin rash, agranulocytosis (rare), aplastic anemia, hepatotoxicity (p.306)

20
Q

What are the toxicities associated with methimazole?

A

Skin rash, agranulocytosis (rare), aplastic anemia; teratogenic (p.306)

21
Q

What is the mechanism of action of levothyroxine?

A

Thyroxide replacement (p.306)

22
Q

What is the mechanism of action of triiodothyronine?

A

Thyroxide replacement (p.306)

Endocrinology (26 decks)

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