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Endocrinology > Endocrine Pharmacology (all) IV > Flashcards

Endocrine Pharmacology (all) IV Flashcards

1
Q

Which drugs are thyroxine replacements?

A

Levothyroxine, triiodothyronine (p.306)

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2
Q

What are the clinical uses for levothyroxine?

A

Hypothyroidism, myxedema (p.306)

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3
Q

What are the clinical uses for triiodothyronine?

A

Hypothyroidism, myxedema (p.306)

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4
Q

What are the toxicities associated with levothyroxine?

A

Tachycardia, heat intolerance, tremors, arrythmias (p.306)

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5
Q

What toxicities are associated with triiodothyronine?

A

Tachycardia, heat intolerance, tremors, arrythmias (p.306)

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6
Q

Name the four hypothalamic/ pituitary drugs.

A

GH, Somatostain (octreotide), Oxytocin, ADH (desmopressin) (p.306)

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7
Q

What are the clinical uses for GH?

A

GH deficiency, Turner syndrome (p.306)

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8
Q

What are the clinical uses for Somatostatin (octreotide)?

A

Acromeagly, carcinoid, gastrinoma, glucagonoma, esophageal varices (p.306)

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9
Q

What are the clinical uses for Oxytocin?

A

Stimulates labour, uterine contractions, milk let down, controls uterine hemorrhage (p.306)

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10
Q

What are the clinical uses for ADH (desmopressin)?

A

Pituitary DI (central, not nephrogenic) (p.306)

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11
Q

What is the mechanism of action of Demeclocycline?

A

ADH antagonist (p.306)

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12
Q

To which drug family does demeclocycline belong?

A

Tetracycline family (p.306)

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13
Q

What is the clinical use for demeclocycline?

A

SIADH (p.306)

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14
Q

What toxicities are associated with demeclocycline?

A

Nephrogenic DI, photosensitivity, abnormalities of the bones and teeth (p.306)

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15
Q

What drugs belong to the glucocorticoids class?

A

Hydrocortisone, prednisone, triamcinolone, dexamethasone, beclomethasone (p.306)

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16
Q

To which drug class does hydrocortisone belong?

A

Glucocorticoids (p.306)

17
Q

To which drug class does prednisone belong?

A

Glucocorticoids (p.306)

18
Q

To which drug class does triamcinolone belong?

A

Glucocorticoids (p.306)

19
Q

To which drug class does dexamethasone belong?

A

Glucocorticoids (p.306)

20
Q

To which drug class does beclomethasone belong?

A

Glucocorticoids (p.306)

21
Q

What is the mechanism of action of glucocorticoid drugs?

A

Decreased production of leukotrienes and prostaglandins by inhibiting phospholipase A2 and expression of COX-2 (p.306)

22
Q

What are the clinical uses for glucocorticoid drugs?

A

Addison’s disease, inflammation, immunosuppression, asthma (p.306)

23
Q

What are the toxicities associated with glucocorticoid use?

A

Iatrogenic Cushing’s syndrome, diabetes (if use is chronic), adrenal insufficiency when drug is stopped abruptly after chronic use (p.306)

Endocrinology (26 decks)

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