Glucocorticod drugs

Question 1

All hormones made in the adrenal are synthesized from

Answer 1

cholesterol…they are steroids

Question 2

ACTH overproduction causes

Answer 2

Cushings

Question 3

ACTH is synthesized as a part of POMC which also contains MSH.

Answer 3

ok

Question 4

What stimulates ACTH release

Answer 4

CRH

Question 5

Corticotrophic releasing hormone secretion is increased in response to what

Answer 5

STRESS, inflammation, hypoglycemia.

Question 6

CRH is normally released 2 hrs before waking daily

Answer 6

ok

Question 7

What would you want to use to see if cortisol is reacting to ACTH properly?

Answer 7

ACTH preferably. But you don’t have that so you use an ACTH analog cosynotropin.

Question 8

What is the deal with corticosteroids and permissiveness?

Answer 8

Corticosteroids increase the effect of epinephrine on lipolysis by increasing protein synthesis

Question 9

Remember, Cortisol and aldosterone both have affinity for the MRs in the kidney that upregulat NaKatpas, Enac, Romk, and SGK1…but what converts cortisol into ——- which has a lower affinity

Answer 9

11 Beta- HYDROXYSTEROID DEHYROGENASE converts cortisol into cortisone

Question 10

Why does Addison’s disease = fatigue

Answer 10

levels of cortisol are required for muscle function

Question 11

Admin of Gluccocorticoids

Answer 11

oral

Question 12

Adverse effects

Answer 12

Osteoporosis, Diabetes, Peptic Ulcers, CNS effects, Small testicles from low testosterone (this is from negative feedback), women (anovulation, dysmenorrhea, uterine bleeding) kids (deceased linear growth from GH/IGF1 inhibition)

Question 13

Hydrocortisone

Answer 13

short acting. cortisol equivalent. Adrenal Insufficiency. Addison’s

Question 14

Cortisone

Answer 14

short acting, oral. .8% potency/Na retention