Drugs affecting Hypothalamic, Pituitary, and Thyroid Function

Question 1

Prolactin rises during pregnancy, remains elevated until birth, falls afterwards unless the mother breastfeeds/

Answer 1

ok

Question 2

What does hyper-prolactinemia cause?

Answer 2

Galactorrhea, amenorhea, infertility –> in women

Poor libido, impotence, infertility—> men

Question 3

Treatment of a prolactinoma

Answer 3

surgery, radiation, Dope Receptor Agonist

Question 4

What is Cabergoline?

Answer 4

A high Affinity Dopa Receptor Agonist….used in treating hyperprolactinemia

Question 5

Growth Hormone release is

Answer 5

pulsatile…makes measuring it meaningless

Question 6

GH release is stimulated by what kind of blood sugar level?

Answer 6

Hypoglycemia…you grow when you’re sleeping and when you’re sleeping you’re fasting.

Question 7

Hyperglycemia and GH

Answer 7

Hyperglycemia inhibits it

Question 8

Test for GH deficiency by injecting insulin and measuring GH response

Answer 8

word

Question 9

What are the 5 viable options for measuring GH

Answer 9

1) measure GH in pooled blood samples taken over 24 hour periods.
2) Measure IGF-1 *****
3) Inject insulin
4) Use standard height charts…not effective
5) Have the pt drink a high fructose soft drink

Question 10

GH and prenatal birth

Answer 10

GH does not affect prenatal birth

Question 11

Adult GH deficiency

Answer 11

Obese, low muscle mass, low CO

Question 12

Somatotropin

Answer 12

Generic GH

Question 13

Adverse Effects of GH tx in kids

Answer 13

HTN, Papilledema, VISUAL DISTURBANCES, HA, LEUKEMIA

Question 14

AE’s of adults GH treatment

Answer 14

increased muscle and bone mass, Low fat, peripheral edema, carpal tunnel, arthralgia/myalgia

Question 15

GH excess =

Answer 15

gigantism and acromegaly

Question 16

GH excess treated with

Answer 16

Ocreotide

Question 17

Ocreotide is what

Answer 17

Somatostatin analog, given in TID injections (there is an extended release form that is given in a slow release once a month injection).

Question 18

FSH and LH

Answer 18

Can be given directly for infertility in anovulatory women, women with hypogonadism, or infertile women that are ovulating.

Only treats infertility in males, not hypogonadism

Question 19

Gosarelin

Answer 19

GnRH agonist for prostate cancer. Increases LH production initially then decreases LH (and thus testosterone) by downregulating receptors

Question 20

Menotropin

Answer 20

Purified old bitch piss. Contains LH and FSH

Question 21

Cetrorelix and Ganirelix

Answer 21

GnRH receptor antagonists that delay the LH surge so that ovulation is delayed and ova have time to develop

Question 22

Levothyroxine

Answer 22

T4. Higher doses required in kids. Can take weeks to reach new steady state levels. Monitor levels closely

Question 23

Liothyronine

Answer 23

L3. tablets or injectable

Question 24

Look at the Thyroid drugs on the sheet

Answer 24

ok