GI: Small & Large Intestines Flashcards
What three features of the small intestines increase surface area by 600x?
mucosal folds, villi, microvilli
What structure has the following characteristics?
- site of new enterocyte production via stem cells
- sit between individual villi
- produce mucus and other secretions
crypts of lieberkuhn
Enterocyte microvilli are also called the…
brush border
What is the basal electrical rhythm from the duodenum to the ileum?
12 to 9/min
What are the two types of movement in the small intestine?
segmentation and peristalsis
This method of motility mixes chyme with juices and exposes it to mucosa…
segmentation
This method of intestinal motility is reflex initiated and moves chyme towards the colon…
peristalsis
The peristaltic reflex is initiated by ________ and mediated by_______
initiated by intestinal lumen distension
mediated by myenteric plexus
Rhythmic segmentation occurs via simultaneous contractions of …
segments of circular muscle
progressive contraction of successive sections of _______ is responsible for peristalsis in the small intestines
circular smooth muscle
In orthograde wave of relaxation/contraction, circular muscle ________ is relaxed while _______ is contracted
relaxed in front of bolus
contracted behind bolus
What mediates circular muscle relaxation in front of the bolus in orthograde wave?
VIP and NO
What mediates circular muscle contraction behind the bolus in orthograde wave?
ACh
This “housekeeping” process occurs with bursts of contractile activity separated by longer periods of quiescence q 75-90 min
Migrating motility complex
where does the migrating motility complex run in the GI?
stomach to ileum
The migrating motility complex is assoc. with increases in plasma _____
motilin
PNS preganglionic fibers synapse with ______ neurons
enteric nervous system neurons
SNS postganglionic fibers synapse with neurons of the _______
myenteric plexus
SNS stimulation of the myenteric plexus has what effect?
inhibit contraction
PNS/Vagal stimulation has what effect on the intestines?
stimulates contractions
The enterogastric intestinal reflex has what mechanism and effect?
increased H+ in duodenal chyme inhibits gastric emptying
The gastroileal intestinal reflex has what mechanism and effect?
Gastric secretion/motility increases ileal motility
What 2 effectors stimulate the gastroileal intestinal reflex?
gastrin and PNS
The ileocecal intestinal reflex has what mechanism and effect?
distension of ileum relaxes ileocecal sphincter
The gastrocolic intestinal reflex has what mechanism and effect?
stomach distension increases colonic motility
4 substances that increase intestinal motility…
ACh, Gastrin, CCK, Motilin
5 substances that decrease intestinal motility…
NE, Somatostatin, Secretin, VIP, GIP