GI - SI & LI pt 3 Flashcards
Johne’s disease
1. AKA what?
2. cause?
3. transmission?
- bovine paratuberculosis
- Mycobacterium avium ssp. Paratuberculosis (MAP)
- fecal-oral, milk, colostrum, water
Johne’s disease: clinical signs and signalment?
chronic diarrhea, emaciation, hypoproteinemia
signalment: domestic ruminants > 18 mos
Johne’s disease: gross lesions?
segmental cerebelliform thickening of the intestine
ileum > cecum and proximal colon
enlarged mesenteric lymph nodes and vessels
Johne’s disease: histo lesions?
infiltration of lamina propria by lots of macrophages
macrophages contain acid-fast bacilli
This is the ileum of a cow. What is the lesion? What is the disease? What is the etiology?
segmental cerebelliform thickening of intestine
Johne’s disease
Mycobacterium avium ssp Paratuberculosis
Johne’s disease is linked to what human condition?
Crohn’s disease
In small ruminants, what gross lesion is most prominent with Johne’s disease?
lymphadenitis > intestinal lesions
what is the etiology of porcine proliferative enteropathy?
Lawsonia intracellularis
porcine proliferative enteropathy:
1. species?
2. signalment?
3. what does the bacteria target?
- pigs > horses, deer, rabbits, dogs, primates, hamsters
- 3wks to adult
- distal SI (ileum) and LI
porcine proliferative enteropathy: gross lesions?
cerebelliform thickening of the intestine
necrotic enteritis
proliferative hemorrhagic enteropathy
These are two examples of pig intestines (distal SI and LI). What disease process causes these lesions?
Porcine proliferative enteropathy caused by Lawsonia intracellularis
What is the etiology of swine dysentery?
Brachyspira hyodysenteriae
What are the gross lesions of swine dysentery? what is the signalment?
mucohemorrhagic to fibrinous colitis
restricted to LI
8wks-adult pigs
These are pig large intestines. What is the lesion? What is the most likely diagnosis? What is the etiology?
Mucohemorrhagic to fibrinous colitis
Swine dysentery
Brachyspira hyodysenteriae
Potomac Horse Fever:
2. etiology?
4. time of year? why?
5. intermediate hosts infect what animals?
6. what should you look at in the farm if you diagnose with this disease?
- Neorickettsia risticii
- summer. requires trematode intermediate host
- snails & aquatic insects
- standing water in the paddock
Potomac Horse Fever: gross lesions
fluid filled large bowel with foul odour (SI affected to lesser extent)
marked edema (distal limbs, laminitis)
What is the new species that causes Potomac Horse Fever?
Neorickettsia finleia sp. nov.
You see this specimen during a necropsy of a horse (large bowel). The horse also had laminitis and distal limb edema, and in the large bowel you took out quite a bit of foul smelling fluid. What is your diagnosis?
Potomac Horse Fever
Is Salmonella zoonotic?
YES
Salmonella: what does it cause?
enterocolitis or septicaemia, diarrhea in any age
Salmonella: gross lesions?
fibrinonecrotizing or catarrhal enteritis and typhlocolitis
multifocal button ulcers
yellow or green feces with foul odour
Tell me what each salmonella entity causes.
1. S. typhimurium in pigs
2. S. dublin in cattle
3. S typhimurium in horses
- chronic rectal strictures
- antibiotic treatment and hospitalization
- fibrinous cholecystitis
You see this small intestine in necropsy and note the button ulcers present. What is your primary differential diagnosis?
Salmonella
Bovine Viral Diarrhea Virus (BVDV): what are the outcomes of infection?
- fetal infection (death, abortion, persistent infection, congenital abnormal.)
- Classical BVD (immunocompetent animals > 6mo, non-cytopathic form, high morbidity low mortality, mild oral ulcers and erosions)
- Severe avute BVD (BVDV2, high morbidity, high mortality, sudden death, diarrhea, pneumonia)
- mucosal disease (developed by PI animals through mutation or infection with cytopathic form)
Bovine viral diarrhea virus: gross lesions?
erosions and ulcers in mouth, rumen, abomasum, cecum/colon
interdigital dermatitis and coronets
linear esophageal ulcers
necrosis and hemorrhage over Peyer’s patches
diarrhea
enlarged mesenteric lymph nodes
This is the esophagus of a cow. What is the lesion? What is the cause of the lesion?
linear erosions/ulcers in esophagus
bovine viral diarrhea virus