GI-Pancreatic Secretions Flashcards
The enzyme component of pancreatic secretions is a … volume concentrate produced by … cells of the Pancreas.
low volume, Acinar
The aqueous component of pancreatic secretions is extremely rich in …, that is the major buffer for incoming gastric acid
HCO3-
The aqueous component of pancreatic secretions is produced primarily by what cells of the Pancreas?
Duct cells
What is released as regulation of Exocrine Secretions of the Pancreas that INHIBITS enzyme secretion via negative feedback?
Pancreatic Polypeptide
The Sympathetic efferents, post-ganglionic fibers from the Celiac and Superior Mesenteric Plexi, have what effect on Pancreatic Secretions?
inhibit
The Parasympathetic efferents via the Vagus nerve terminate at the acini and are … to Acinar Cell production and release of Enzyme.
stimulatory
What is the primary stimulator of Pancreatic H2O/HCO3- release?
Duodenal Secretin
Where are enzymes first created and subsequently transferred to?
RER –> GA
What released from the duodenal mucosa in response to chyme mediates Pancreatic Enzyme release?
CCK
What phase of Digestion stimulates the greatest influence on Pancreatic Secretions (~70%)
Intestinal Phase
What are the primary substances that stimulate the Pancreas?
Secretin, CCK, and ACh via Vago-Vagal Reflexes
Stimulation of the Duodenal Mucosa Chemoreceptors by a pH
S-Cells
S-cells produce and release Secretin, which increases the activity of …
Ductal Region and Aqueous component
Stimulation of the Duodenal Mucosa Chemoreceptors by fats and proteins results in the stimulation of … release from … cells
CCK from I-Cells
CCK circulates to the Pancreas where it acts on the … to …
Pyramidal Acinar Cells to increase production and release of the Enzyme component
