Genetics Flashcards

1
Q

What is a Genotype?

A

All genes that make up an organism’s genetic composition.

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2
Q

What is Helicase?

A

Enzyme that unwinds and unzips DNA during replication.

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3
Q

What does DNA Polymerase III do?

A

Adds bases to a new DNA strand in the 5’ → 3’ direction.

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4
Q

What is the function of Ligase?

A

Enzyme that seals nicks in DNA strands.

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5
Q

What is Semiconservative Replication?

A

DNA replication where each new molecule has one old and one new strand.

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6
Q

What is a Replication Fork?

A

The site where DNA strands are unwound and replication occurs.

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7
Q

What is a Primer?

A

Short RNA sequence added to start DNA synthesis before being replaced by DNA.

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8
Q

What is a Leading Strand?

A

Continuously synthesized DNA strand in the 5’ → 3’ direction.

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9
Q

What is a Lagging Strand?

A

Discontinuously synthesized DNA strand, made in Okazaki fragments.

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10
Q

What are Okazaki Fragments?

A

Short DNA segments synthesized on the lagging strand.

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11
Q

What is the role of Topoisomerase?

A

Relieves tension in DNA strands during replication.

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12
Q

What is the Central Dogma?

A

The flow of genetic information: DNA → transcription → mRNA → translation → protein.

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13
Q

What is mRNA?

A

Carries genetic information from DNA to ribosomes for protein synthesis.

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14
Q

What is tRNA?

A

Transfers amino acids to ribosomes during protein synthesis.

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15
Q

What is rRNA?

A

Forms the major part of ribosomes and facilitates protein synthesis.

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16
Q

What is Wobble?

A

Flexibility in base pairing at the third codon position, allowing redundancy in the genetic code.

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17
Q

What is Translocation?

A

The movement of ribosomes along mRNA to read new codons.

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18
Q

What is Eukaryotic Translation?

A

Occurs separately from transcription; AUG codes for methionine; one protein per mRNA.

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19
Q

What is Prokaryotic Translation?

A

Occurs simultaneously with transcription; mRNA can code for multiple proteins.

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20
Q

What is an Operon?

A

A cluster of genes controlled by a single promoter, common in prokaryotes.

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21
Q

What is an Inducible Operon?

A

Turned on by a substrate (e.g., lactose operon).

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22
Q

What is a Repressible Operon?

A

Turned off by excess product (e.g., tryptophan operon).

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23
Q

What is Phase Variation?

A

Bacteria switching genes on/off to change phenotype.

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24
Q

What is Horizontal Gene Transfer?

A

Transfer of DNA between bacteria, not parent to offspring.

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25
Q

What is Conjugation?

A

DNA transfer between bacteria via a pilus.

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26
Q

What is Transformation?

A

Bacteria take up foreign DNA from the environment.

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27
Q

What is Transduction?

A

Bacteriophages transfer DNA from one bacterial cell to another.

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28
Q

What is Generalized Transduction?

A

Random DNA fragments are incorporated into a phage and transferred.

29
Q

What is Specialized Transduction?

A

Specific bacterial genes are incorporated into a virus.

30
Q

What are Transposons?

A

Jumping genes that move within the genome.

31
Q

What is a Point Mutation?

A

A mutation affecting a single base in DNA.

32
Q

What is a Missense Mutation?

A

A mutation that results in a different amino acid in a protein.

33
Q

What is a Nonsense Mutation?

A

A mutation that converts a codon into a stop codon, halting translation.

34
Q

What is a Silent Mutation?

A

A mutation that changes the DNA sequence but not the amino acid sequence.

35
Q

What is a Frameshift Mutation?

A

Insertion or deletion of bases altering the reading frame.

36
Q

What is a Lethal Mutation?

A

A mutation that results in cell dysfunction or death.

37
Q

What is a Back Mutation?

A

A mutation that reverts a gene back to its original form.

38
Q

What is Photoreactivation?

A

Repairing DNA damage caused by UV light.

39
Q

What is Excision Repair?

A

Enzymes remove and replace incorrect DNA bases.

40
Q

What is the Ames Test?

A

A test that detects mutagenic and potentially carcinogenic substances.

42
Q

What is the basic unit of heredity?

43
Q

True or False: DNA stands for Deoxyribonucleic Acid.

44
Q

Fill in the blank: The process of copying DNA to RNA is called _____.

A

Transcription

45
Q

What are the four nucleotide bases in DNA?

A

Adenine, Thymine, Cytosine, Guanine

46
Q

Which base pairs with Adenine in DNA?

47
Q

What is the function of ribosomes in protein synthesis?

A

To translate mRNA into protein.

48
Q

True or False: All mutations are harmful.

49
Q

What is the term for an organism’s observable traits?

50
Q

What does the term ‘homozygous’ mean?

A

Having two identical alleles for a particular gene.

51
Q

In a Punnett square, what do the letters represent?

A

Alleles of the parents.

52
Q

What is the role of messenger RNA (mRNA)?

A

To carry genetic information from DNA to the ribosome.

53
Q

Fill in the blank: The physical location of a gene on a chromosome is called its _____.

54
Q

What is genetic variation?

A

Differences in DNA sequences among individuals.

55
Q

True or False: A phenotype can be influenced by environmental factors.

56
Q

What is the term for a segment of DNA that codes for a protein?

57
Q

Which process involves the splitting of a cell’s nucleus?

58
Q

What is the difference between a dominant and a recessive allele?

A

A dominant allele expresses itself even in the presence of a different allele, while a recessive allele only expresses itself when two copies are present.

59
Q

Fill in the blank: The study of heredity is known as _____.

60
Q

What is a genotype?

A

The genetic constitution of an organism.

61
Q

True or False: Chromosomes are made of DNA and proteins.

62
Q

What does the term ‘allele’ refer to?

A

Different forms of a gene.

63
Q

What is the purpose of genetic engineering?

A

To modify the genetic makeup of an organism.

64
Q

Fill in the blank: A trait controlled by multiple genes is called _____.

A

Polygenic trait

65
Q

What is the role of transfer RNA (tRNA) in protein synthesis?

A

To bring amino acids to the ribosome during translation.

66
Q

What are chromosomes made of?

A

DNA and proteins.

67
Q

True or False: All genes are expressed equally in all cells.

68
Q

What is the term for the observable characteristics of an organism?