General

Question 0

Where does drug metabolism mostly occur?

Answer 0

Liver

Question 1

What happens in Phase 1 of drug metabolism?

Answer 1

Chemical structure is modified and drug is made more water soluble

Question 3

How are most drug metabolites excreted?

Answer 3

Urine

Question 4

Give an example of a drug that acts on receptors

Answer 4

Salbutamol

Question 5

What is meant by the term ‘pharmacological activation’?

Answer 5

Products of Phase 1 are more chemically reactive than the parent drug

Question 6

Give an example of a drug that acts on enzymes

Answer 6

ACE Inhibitors

Question 7

Give an example of a drug that acts on carrier molecules

Answer 7

Ompemprazole

Question 8

Give an example of a drug that acts on ion channels

Answer 8

Furosemide, lidocaine

Question 9

What is the role of a 2nd messenger?

Answer 9

Trigger a cascade of reactions that lead to the goal of the drug being achieved

Question 12

What happens in Phase 2 of metabolism?

Answer 12

Drug is conjugated with larger molecules. They are inactivated and water soluble