General Flashcards

0
Q

Where does drug metabolism mostly occur?

A

Liver

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1
Q

What happens in Phase 1 of drug metabolism?

A

Chemical structure is modified and drug is made more water soluble

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3
Q

How are most drug metabolites excreted?

A

Urine

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4
Q

Give an example of a drug that acts on receptors

A

Salbutamol

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5
Q

What is meant by the term ‘pharmacological activation’?

A

Products of Phase 1 are more chemically reactive than the parent drug

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6
Q

Give an example of a drug that acts on enzymes

A

ACE Inhibitors

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7
Q

Give an example of a drug that acts on carrier molecules

A

Ompemprazole

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8
Q

Give an example of a drug that acts on ion channels

A

Furosemide, lidocaine

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9
Q

What is the role of a 2nd messenger?

A

Trigger a cascade of reactions that lead to the goal of the drug being achieved

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12
Q

What happens in Phase 2 of metabolism?

A

Drug is conjugated with larger molecules. They are inactivated and water soluble

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