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Pharmacology > Applied Pharm - Anti-Microbials > Flashcards

Applied Pharm - Anti-Microbials Flashcards

1
Q

What are bacterial essential structures? (3)

A

Plasma membrane, protein synthesis, cell wall

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2
Q

Name 3 gram +ve bacteria

A

Staphylococcus
Streptococcus
Entercoccus

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3
Q

Name 3 gram -ve bacteria

A

E.Coli
Pseudomonas
Salmonella

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4
Q

Name 4 types of ABX that act of peptodoglycan synthesis

A

Penicillins
Cephalosporins
Carbapenems

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5
Q

WHat name is given to the class of ABX that target PG synthesis?

A

Beta lactams

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6
Q

Name 2 types of penicillin

A

Amoxicillin

Ampicillin

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7
Q

What are penicillins most efective against?

A

Gram positive bacteria

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8
Q

Which cephalosporins are effective against gram positive bacteria?

A

Cefalexin

Cefazolin

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9
Q

Which cephalosporins are effective against gram negative bacteria?

A

Cefixime

Cefpodoxime

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10
Q

Which cephalosporins are effective against anaerobes?

A

Cefaclor

Cefuroxime

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11
Q

Which cephalosporins are effective against pseudomonas?

A

Cefepime

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12
Q

What are carbapenems effective against?

A

Everything but MRSA and VRE

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13
Q

Name 3 carbapenems

A

Metropenem
Ertapenem
Imipenem

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14
Q

What is vancomycin

A

Cell wall inhibitor

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15
Q

Name a ABX that inhibits RNA

A

Rifampicin

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16
Q

Name 3 ABX that act of the 30S component

A

Tetracycline
Gentamycin
Streptomycin

17
Q

Name 3 ABX that act of the 50S component

A

Erythromycin

Chloramphenicol

18
Q

Name 3 characteristics of protein synthesis inhibitors

A

Broad Spectrum
Bacteriostatic
Greater toxicity

19
Q

Name 4 Fluororquinolones

A

Ciprofloxacin
Norfloxacin
Levofloxacin
Moxifloxacin

20
Q

What is fluoroquinolones mechanism of action?

A

Inhibits DNA synthesis

21
Q

What are presentations of fungaldisease called?

A

Mycoses

22
Q

Name a commensal fungi

A

Candida albicans

23
Q

Name 2 environmental fungi

A

Aspergillus fumigatus

Crytococcus neoformans

24
Q

What causes vaginitis

A

Candida albicans

25
Q

What makes up 55-60% of fungal cell walls

A

Glucan

26
Q

What makes up 2% of fungal cell walls

A

Chitin

27
Q

What makes up 35-50% of fungal cell walls

A

Manan

28
Q

Name 2 anti-fungals that are 1,3 Glucan inhibitors

A

Caspofungin

Micafungin

29
Q

How do 1,3 inhibitors work

A

Inhibit enzymes, block synthesis

30
Q

What do fungal membranes contain that human cells don’t?

A

Ergosterol

31
Q

What are azoles?

A

Ergosterol synthesis inhibitors

32
Q

How do azoles work?

A

Inhibit Lanosterol C-14 demethylase

33
Q

Name 3 Imidazoles

A

Miconazole
Clotrimazole
Ketoconazole

34
Q

Name 3 triazoles

A

Fluconazole
Voriconazole
Itraconozole

35
Q

Name 3 Allylamines

A

Terbinafine

Amorolfine

36
Q

What is Flucytosine metabolised to?

A

Fluorouracil

37
Q

What does fluouracil do to fungi

A

Inhibits DNA/RNAsynthesis

Pharmacology (18 decks)

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