Applied Pharm - Chemotherapy

Question 1

3 objectives of chemo?

Answer 1

Cure patient
Prolong life
Palliative treatment

Question 2

Name 5 toxic effects of chemo

Answer 2

Bone marrow suppression
GI damage
Sterility
Poor healing
Hair loss

Question 3

4 classes of cytotoxic drugs?

Answer 3

Alkylating agents
Antimetabolites
Antibiotics
Plant derivatives

Question 4

How do alkylating agents work?

Answer 4

Block DNA synthesis by forming bonds with DNA

Question 5

Name 3 classes of alkylating agent

Answer 5

Nitrogen mustards, nitrosoureas, platinum compounds

Question 6

Name 2 nitrogen mustards

Answer 6

Mechlorethamine

Cyclophosphamide

Question 7

Name a risk of alkylating agents

Answer 7

Sterility

Question 8

What is a risk of acrolein

Answer 8

Heamorrhagic cystitis

Question 9

Name 2 nitrosoureas

Answer 9

Carmustine

Lomustine

Question 10

What do platinum compounds bind to?

Answer 10

Purine bases

Question 11

Name 3 platinum compounds

Answer 11

Cisplatin
Carboplatin
Oxaliplatin

Question 12

Name 3 misc alkylating agents

Answer 12

Busulfan
Procarbazine
Trabectadin

Question 13

Name a folate antagonist

Answer 13

Methotrexate

Question 14

Name 3 classes of anti-metabolites

Answer 14

Folate antagonists
Purine analogues
Pyrimidine analogues

Question 15

What do pyrimidine analogues compete with?

Answer 15

T and C

Question 16

Name 4 pyrimidine analogues

Answer 16

Fluorouracil
Capecitabine
Cytarabine
Gemcitabine

Question 17

Name 4 purine analogues

Answer 17

Mercaptopurine
Tioguanine
Pentostatin
Fludarabine

Question 18

Name 4 cytotoxic ABX

Answer 18

Bleomycin
Doxorubicin
Dactinomycin
Mitomycin

Question 19

What is the risk of using doxorubicin?

Answer 19

Local necrosis if spilt on skin

Question 20

What are vinca alkaloids derived from?

Answer 20

Madasgascan periwinkle

Question 21

Name 3 vinca alkaloids

Answer 21

Vincristine
Vinblastine
VIndesin

Question 22

How do vinca alkaloids work?

Answer 22

Prevent spindle formation

Question 23

What are taxanes derived from?

Answer 23

Yew tree bark

Question 24

Name 2 taxanes

Answer 24

Paclitaxel

Docetaxel

Question 25

What are eptoposides derived from?

Answer 25

Mandrake root

Question 26

Side effects of eptoposides?

Answer 26

Rapid BP decrease during IV

Question 27

Name 2 oestrogen chemo meds

Answer 27

Ethinyloestradiol

Diethylstilbestrol

Question 28

What are oestrogens commonly used for?

Answer 28

Prostate cancer

Question 29

Name 3 progestogens

Answer 29

Megestrol
Norethisterone
Medoxyprogesterone

Question 30

What are progestogens used for?

Answer 30

Endometrial ca

Question 31

Name 4 GnRH analogues

Answer 31

Goserelin
Buserelin
Leuprorelin
Triptorelin

Question 32

What are GnRH analogues used for?

Answer 32

prostate and breast cancer

Question 33

Name 2 somatostatin analogues

Answer 33

Octreotide

Lanreotide

Question 34

What are somatostain analogues used for

Answer 34

Hormone secreting tumours in GI tract

Question 35

How do monoclonal antibodies work?

Answer 35

Activate immune system to lyse cancer cells

Question 36

Name 4 monoclonal antibodies

Answer 36

Rituximab
Trastuzumab
Ofatumumab
Bevacizumab

Question 37

Name 3 protein kinase inhibitors

Answer 37

Imatinib
Dasatinib
Nilotinib

Question 38

What does lenograstim do?

Answer 38

Boosts stem cell production

Question 39

What is autologous transplant mean?

Answer 39

Stem cells from own patient

Question 40

What does allogenic transplant mean?

Answer 40

From a donor