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Pharmacology > Applied Pharm - Anti-Depressents > Flashcards

Applied Pharm - Anti-Depressents Flashcards

1
Q

Name 2 MAOIs

A

Phenelxine and Tranylcypromine

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2
Q

What are the adverse effects of MAOIs? (6)

A

Hypertensive crisis, Cytochrome P450 inhibition, weight gain, oedema, sedation, sexual dysfunction

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3
Q

What does MAOI stand for?

A

Monoamine oxidase inhibitor

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4
Q

Name 2 5HT releasers

A

Fenfluramine

MDMA

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5
Q

What do 5HT1A - F receptors do?

A

Decrease cAMP

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6
Q

What do 5HT4,6, 7, 5A and 5b receptors do?

A

Increase cAMP

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7
Q

What do 5HT2A - C receptors do?

A

increase inositol, phosphates and calcium

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8
Q

Name 4 tricyclic anti-depressants

A

Desipramine
Imipramine
Amitryptiline
Doxepen

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9
Q

Name 4 SSRIs

A

Fluoxetin
Sertraline
Paroxetine
Citalopram

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10
Q

What are the adverse effects of tricycle anti-d’s? (6)

A

Weight gain, sedation, sexual dysfunction, cytochrome P450 inhibition, dry mouth, dizziness

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11
Q

What are the adverse effects of SSRIs? (3)

A

Dependence, withdrawal, sexual dysfunction

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12
Q

What are the contraindications for tricyclic anti-d’s? (2)

A

MI

Coronary artery disease

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13
Q

What drugs should be avoided when using tricyclic anti-d’s?

A

Anti-histamines, CNS depressants

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14
Q

What are the contraindications for SSRIs?

A

Previous mania or anxiety

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15
Q

What drugs should be avoided when using SSRIs?

A

MAOIs, warfarin

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16
Q

What are the contraindications for MAOIs? (4)

A

Renal/hepatic dysfunction, hypertension, pregnancy and lactation

17
Q

Name 2 next generation anti-d’s

A

Bupropion

Venlafaxine

18
Q

Name 4 mood stabilising drugs

A

Lithium carbonate
Lithium citrate
Valproate
Carbamazepine

19
Q

What are the contraindications for mood stabilisers? (4)

A

Renal dysfunction
Leukaemia
Dehydration
Sodium depletion

20
Q

What adverse effects do mood stabilisers have? (7)

A

Headache, dizziness, confusion, hair loss, oedema, arrhythmia, withdrawal

21
Q

What drugs should be avoided with mood stabilisers? (3)

A

NSAIDS, anti-psychotics, diuretics

22
Q

Name 4 anti-psychotics

A

Chlorpromazine
Loxapine
Fluphenazine
Haloperidol

23
Q

What are the contraindications for anti-psychotics? (7)

A

CVD, bone marrow depression, renal/liver/thyroid dysfunction, Parkinson’s

24
Q

WHat are the adverse effects of anti-psychotics? (5)

A

Parkinsonism, sedation, hypotension, impaired thermoregulation, tardive dyskinesia

25
Q

What drugs should be avoided with anti-psychotics? (4)

A

CNS depressants, anti-convulsants, hypertension meds and antacids

26
Q

Name 4 sedative hypnotics

A

Thiopental
Secobarbital
Zolpidem
Phenobarbital

27
Q

What adverse effects doe sedative hypnotics have? (4)

A

Drowsiness, hangover, tolerance, dependence

28
Q

What contraindications for sedative hypnotics? (3)

A

Under 18s, pregnancy and lactation

29
Q

What drugs should be avoided with sedative hypnotics?

A

CNS depressants

30
Q

Name a non-benzo anxiolytic

A

Buspirone

31
Q

What are the adverse effects of buspirone? (6)

A

dizziness, headaches, insomnia, dry mouth, blurred vision, palpitations

32
Q

What drugs should be avoided with Buspirone?

A

CNS depressants, MAOIs

33
Q

Name 4 benzo anxiolytics

A

Diazepam
Alprazolam
Temazepam
Lorazepam

34
Q

Adverse affects of benzos? (6)

A

Over sedation, headache, dry mouth, blurred vision, memory loss, hypotension

35
Q

contraindications for benzos? (4)

A

Renal/liver dysfunction, pregnancy, lactation

36
Q

Name 4 atypical anti-psychotics

A

Clozapine
Amisulpride
Risperidone
Olanzepine

37
Q

What are the adverse effects of atypical anti-psychotics? (12!)

A

headache, blurred vision, photo-sensitivity, insomnia, nervosness, dizziness, GI distress, weight gain, ulcers, glaucoma, retention, liver dysfunction

38
Q

Dugs to avoid with atypical anti-psychotics?

A

CNS depressants, anti-hypertensives

Pharmacology (18 decks)

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