Coagulation

Question 1

What has a major role in arterial thrombosis

Answer 1

Platelet aggregation however coagulation is also involved

Question 2

What is thrombosis

Answer 2

The formation of a thrombus within a vessel

Question 3

What is an embolus

Answer 3

Fragment or whole thrombus detached from blood vessel wall which travels through blood vessels

Question 4

What is an anticoagulant

Answer 4

Helps prevent blood clots

Question 5

Where is heparin present in the body

Answer 5

Liver, lungs and mast cells (natural)

Question 6

How is heparin administered

Answer 6

Via injection

Question 7

What does heparin activate

Answer 7

Antithrombin

Question 8

What does Antithrombin inactivate

Answer 8

Thrombin & Factors Xa

Question 9

How is warfarin administered

Answer 9

Orally

Question 10

What does warfarin do?

Answer 10

Decreases body’s ability to form clots by blocking the formation of Vitamin K depending clotting factors

Question 11

What does warfarin activate

Answer 11

Factor II (prothrombin)

Question 12

What are the problems associated with warfarin

Answer 12

Slow onset 
Activation influenced by Vitamin K 
Many interactions e.g. Drugs, food 
Monitored using 'international normalised ratio' (INR)
Risk of haemorrhage

Question 13

What does teratogenic mean

Answer 13

Something that can cause a birth defect

Question 14

What other drugs should warfarin not be taken with

Answer 14

Carbamazepine and Cimetidine

Question 15

What other anticoagulants could potentially replace warfarin

Answer 15

Rivaroxaban (Xarelto) & Dabigatran (Pradaxa)

Question 16

What has a major role in Venous thrombosis

Answer 16

Coagulation