Gas Transport Flashcards
What is the PAO2 of the environment
150 mmHg
What is the PaO2 and PaCO2 of Arterial blood
O2 - 95 mmHg
CO2 - 40 mmHg
What is the PaO2 and PaCO2@ of venous blood
O2 - 40 mmHg
CO2 - 45 mmHG
What is the soluablitity of dissolved O2 in the blood
0.3ml/dl of blood/100 mmHg
Not enough to meet metabolic needs
How much O2 and CO2 respectively are moved in and out of lungs a minute
250 ml O2
200 ml CO2
The amount of dissolved O2 in the blood (PaO2) is in equilibrium with what
The O2 on hemoglobin
Any PO2 > 60 mmHb, what is O2 sat.?
Atleast 85%
Hb allows how much O2 to be delivered per dl of blood
17ml
What does a L shift indicate
An increased affinity of Hb for O2 (in the lungs)
What does a R shift represent
A decrease in affinity of Hb for O2
What happens to the oxygen Hb curve during working out
L shift in lungs, but a R shift in tissues (Good)
High CO2 and low pH do what to the curve
What about low Co2 and high pH
RS
LS
High CO2, temp, and 2,3 DPG are found where? What does this mean for the curve
Found in tissues, this means there is a RS which is good, allows for tissues to receive oxygen from Hb
What is the O2 content of venous blood
15 ml O2/dl blood
Define the a-v O2 difference (equation)
PaO2 - PVo2
Represents how much Oxygen was used by the tissue
Comes top 4.6 in a healthy individual
RQ for carbs, FFA, and mixed
Carbs - 1
FFA - 0.7
Mix - 0.8 (normal)
Define respiratory quotient and give the equation
The ration between Co2 produced and the O2 consumed
RQ = Vdot CO2/Vdot O2
What is the solubility of CO2
20x that of O2
6ml O2/dl blood/100 mmHg
There is about how much CO2 dissolved in each Dl of blood
2.7 ml CO2
What is the main carrier of CO2 from the blood to the alveoli
HCO3
What enzyme facilitates the change of H2CO3 into HCO3
Carbonic anhydrase
Define the chloride shift and its clinical signifance
Cl shifts into cells which allows for HCO3 to leave cells
So less Cl will not allow for adequate HCO3 transport and this more CO2 in blood and lower pH (acidic)
How does dissolved CO2 travel in the lungs
Down its concentration gradient
How does the movement of dissolved CO2 in the alv. Capillaries facilitate movement of CO2 from HCO3
Dissolved CO2 moves down concentration gradient which decreases the CO2 in the alv. Cap. This causes CO2 in the equation to drop and thus HCO3 is converted back into CO2 and H2O (moving the reaction backward)
