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BPM1 Exam 2 - Foundations to Medicine 2 > FTM 75-76 - Nervous System Pharmacology > Flashcards

FTM 75-76 - Nervous System Pharmacology Flashcards

1
Q

What are the 7 mechanisms of actions for the cholinergic drugs we need to know?

A

ACh release inhibition

Reversible Anticholinesterases

Irreversible Anticholinesterases

Neuromuscular Nicotinic Agonists

Neuromuscular Nicotinic Antagonists

Muscarinic Agonists

Muscarinic Antagoinists

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2
Q

What are the 14 mechanisms of action for the adrenergic drugs we need to know?

A

Inhibition of CA storage, reuptake, or metabolism

α & ß agonists

α1 and/or α2 agonists

α1 & α2 antagonist

α1 antagonist

ß1 or ß2 agonist

Non selective ß blocker

Selective ß blocker

Partial agonists

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3
Q
A
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4
Q

What is the mechanism of action for Botox?

A
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5
Q

Compare and contrast Lambert-Eaton with Myasthenia Gravis. What types of drugs are best to treat these conditions?

A
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6
Q

Facts to know about edrophonium

A
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7
Q

Facts to know about Neostigmine and Physostigmine

A
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8
Q

Facts to know about Malathion

A
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9
Q

What are the positives of AChE inhibitors?

A
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10
Q

What are the negatives of AchE inhibitors?

A
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11
Q

Which clinical conditions would benefit from a muscarinic receptor agonist?

A
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12
Q

Why isn’t ACh used as a muscarinic receptor agonist?

A

It has a very short half life

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13
Q

Facts to know about Pilocarpine, Bethanecol, and Methacholine.

A
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14
Q

What is the muscarinic antagonist we need to know? What is its mode of action? What actions does it elicit in the body?

A
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15
Q

What are the clinical uses of atropine?

A
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16
Q

Facts to know about Succinylcholine

A
17
Q

Facts to know about Pancuronium

A

It is a non depolarizing neuromuscular blocker which means it is a competitive antagonis of Nm receptors on skeletal muscle. It causes flaccid paralysis and is used to relax skeletal muscles during surgery, to induce anesthesia, intubation, or using a ventilator. Its effect can be overcome using a AchE inhibitor.

Side effects: hypertension, apnea, bronchospasm, salivation, flushing and respiratory failure

18
Q

Differentiate succhinylcholine from pancuronium

A
19
Q
A
20
Q

Discuss the receptor affinities for Epinephrine and Norepinephrine

A
21
Q

Discuss the potencies of E and NE at the different receptors.

A
22
Q

Facts to know abou Phenylephrine

A

It is an α1 agonist that is used as a nasal decongestant and to treak shock

Side Effects: hypertension

23
Q

Facts to know about Prazosin

A

α1 antagonist used to treat hypertension and benign prostatic hyperplasia

Side effects: postural orthostatic hypotenstion related to 1st dose phenomena

24
Q

Facts to know about Tamsulosin

A

α1 antagonist used to treat benign prostatic hyperplasia. It is more selective for genitourinary smooth muscle receptor subtype α1A

Side effects - postural/orthostatic hypotension (but less than prazosin)

25
Q

Facts to know about clonidine

A
26
Q

Facts to know about Oxymetaxoline

A
27
Q

Facts to know about phenoxybenzamine and phentolamine

A
28
Q

Facts to know about dobutamine

A
29
Q

Facts to know about albuterol

A
30
Q

Facts to know about Pindolol

A
31
Q

Facts to know about atenolol

A
32
Q

Facts to know about Propranolol

A
33
Q

What are the three primary actions of amphetamines?

A
34
Q

Facts to know about Ephedrine & Pseudoephedrine

A

inhibitors of catecholamine storage

35
Q

Facts to know about Cocaine and Imipramine

A

Inhibitors of catecholamine re-uptake

36
Q

Facts to know about Iproniazid

A

It is an irreversible and nonselective inhibitor of MAOIs which degrade serotonin, NE, and dopamine. Results in high NE concentration in cytosol. Used in treatment of mild depression. Discontinued in most of the world due to the Cheese Reaction

37
Q

What is the cheese reaction

A

BPM1 Exam 2 - Foundations to Medicine 2 (29 decks)

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