FTM 75-76 - Nervous System Pharmacology Flashcards
What are the 7 mechanisms of actions for the cholinergic drugs we need to know?
ACh release inhibition
Reversible Anticholinesterases
Irreversible Anticholinesterases
Neuromuscular Nicotinic Agonists
Neuromuscular Nicotinic Antagonists
Muscarinic Agonists
Muscarinic Antagoinists
What are the 14 mechanisms of action for the adrenergic drugs we need to know?
Inhibition of CA storage, reuptake, or metabolism
α & ß agonists
α1 and/or α2 agonists
α1 & α2 antagonist
α1 antagonist
ß1 or ß2 agonist
Non selective ß blocker
Selective ß blocker
Partial agonists
What is the mechanism of action for Botox?
Compare and contrast Lambert-Eaton with Myasthenia Gravis. What types of drugs are best to treat these conditions?
Facts to know about edrophonium
Facts to know about Neostigmine and Physostigmine
Facts to know about Malathion
What are the positives of AChE inhibitors?
What are the negatives of AchE inhibitors?
Which clinical conditions would benefit from a muscarinic receptor agonist?
Why isn’t ACh used as a muscarinic receptor agonist?
It has a very short half life
Facts to know about Pilocarpine, Bethanecol, and Methacholine.
What is the muscarinic antagonist we need to know? What is its mode of action? What actions does it elicit in the body?
What are the clinical uses of atropine?
Facts to know about Succinylcholine
Facts to know about Pancuronium
It is a non depolarizing neuromuscular blocker which means it is a competitive antagonis of Nm receptors on skeletal muscle. It causes flaccid paralysis and is used to relax skeletal muscles during surgery, to induce anesthesia, intubation, or using a ventilator. Its effect can be overcome using a AchE inhibitor.
Side effects: hypertension, apnea, bronchospasm, salivation, flushing and respiratory failure
Differentiate succhinylcholine from pancuronium
Discuss the receptor affinities for Epinephrine and Norepinephrine
Discuss the potencies of E and NE at the different receptors.
Facts to know abou Phenylephrine
It is an α1 agonist that is used as a nasal decongestant and to treak shock
Side Effects: hypertension
Facts to know about Prazosin
α1 antagonist used to treat hypertension and benign prostatic hyperplasia
Side effects: postural orthostatic hypotenstion related to 1st dose phenomena
Facts to know about Tamsulosin
α1 antagonist used to treat benign prostatic hyperplasia. It is more selective for genitourinary smooth muscle receptor subtype α1A
Side effects - postural/orthostatic hypotension (but less than prazosin)
Facts to know about clonidine
Facts to know about Oxymetaxoline
Facts to know about phenoxybenzamine and phentolamine
Facts to know about dobutamine
Facts to know about albuterol
Facts to know about Pindolol
Facts to know about atenolol
Facts to know about Propranolol
What are the three primary actions of amphetamines?
Facts to know about Ephedrine & Pseudoephedrine
inhibitors of catecholamine storage
Facts to know about Cocaine and Imipramine
Inhibitors of catecholamine re-uptake
Facts to know about Iproniazid
It is an irreversible and nonselective inhibitor of MAOIs which degrade serotonin, NE, and dopamine. Results in high NE concentration in cytosol. Used in treatment of mild depression. Discontinued in most of the world due to the Cheese Reaction
What is the cheese reaction
