FTM 60-61 - Population Genetics 1 & 2

Question 1

Answer 1

E

Question 2

Answer 2

6

Question 3

Answer 3

0. 18
1. 01

Question 4

Answer 4

E

Question 5

How can you simplify the HW equation for autosomal recessive disorders?

Answer 5

Question 6

How is the frequency of an autosomal recessive disease causing allele calculated from the incidence of the disease in the population?

Answer 6

Question 7

Answer 7

~1/25

Question 8

What is the calculation simplification rule for the HW equation?

Answer 8

Question 9

Answer 9

4

Question 10

Answer 10

B

Question 11

Answer 11

5

Question 12

Answer 12

4

Question 13

Answer 13

5

Question 14

Answer 14

Question 15

Answer 15

1/90,000

1/1600

Question 16

The incidence of hemophilia in a population is 1/10,000 males. Calculate how many diseased females are present in the population and how many carrier females there are.

Answer 16

Question 17

How do calculate q from a known affected incidence rate for an autosomal dominant disease?

Answer 17

Question 18

What are the assumptions of Hardy-Weinberg Equilibrium?

Answer 18

Question 19

What four primary factors will cause genetic variation within a population?

Answer 19

Question 20

What disease, besides sickle cell, is protective against malaria?

Answer 20

ß-thalassemia

Question 21

What does the term “reproductive fitness” refer to?

Answer 21

The likelihood an organism will survive to reproductive age and be fertile

Question 22

What diseases result in zero reproductive fitness?

Answer 22

Tay-Sach’s disease

Turner Syndrome

Question 23

How does Huntington disease affect reproductive fitness?

Answer 23

It doesn’t becuase it usually does not manifest until will past the reproductive age

Question 24

How does PKU affect reproductive fitness?

Answer 24

If untreated it reduces it due to intellectural disability. Properly treated PKU results in normal fitness

Question 25

What is genetic drift?

Answer 25

Allele frequency tends to rise and fall slightly within populations. If a population is small enough this fluctuation could fix or extinguis an allele.

Question 26

What is the founder effect?

Answer 26

A special case of genetic drift. It is the loss of genetic variation that occurs when a new population is established by a very small number of individuals from a larger population.

Question 27

Answer 27

E

Question 28

Answer 28

Question 29

What are some of the more common reasons a mutant allele may have a high frequency in a population?

Answer 29