Finals week RA drugs Flashcards

1
Q

What is the action of Methrotrexate?

A

Blocks dihyrdofolate reductase (anti-folate)

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2
Q

What is the mechanism of hydroxychloroquine?

A

Prevents acidification of macrophage cytosol by blocking TLR-9

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3
Q

What is the mechanism of Leflunomide

A

Inhibits pyrimidine synthesis (blocks ororate pathway)

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4
Q

What is the mechanism of sulfasalazine

A

Pro-drug that gets converted into sulfapyridine (free radical scavenger), and 5 amino-salicylic acid (COX antagonist)

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5
Q

What is the mechanism of gold?

A

Suppresses phagocytosis by macrophages, suppresses antigen presentation and T cells

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6
Q

What is the mechanism of Azathioprine?

A

Blocks DNA synthesis primarily in T cells

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7
Q

What is the mechanism of cyclosporin?

A

Calcineurin inhibitor to inhibit T cell activation

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8
Q

What is the mechanism of Etanercept and Inflixumab

A

Blocks DNA TNF action

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9
Q

What is the mechanism of anakinra?

A

IL-1 receptor antagonist

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10
Q

What is the mechanism of abatacept?

A

Blocks T cell activation by antigen presenting cell (Binds CD80)

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11
Q

What is the mechanism of Ritixumab

A

Blocks B cell activation (Binds CD20)

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12
Q

What are the 4 options for RA treatment?

A

NSAIDs, Corticosteroids, Non-biological DMARDs, Biological DMARDs

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