Finals week RA drugs Flashcards
What is the action of Methrotrexate?
Blocks dihyrdofolate reductase (anti-folate)
What is the mechanism of hydroxychloroquine?
Prevents acidification of macrophage cytosol by blocking TLR-9
What is the mechanism of Leflunomide
Inhibits pyrimidine synthesis (blocks ororate pathway)
What is the mechanism of sulfasalazine
Pro-drug that gets converted into sulfapyridine (free radical scavenger), and 5 amino-salicylic acid (COX antagonist)
What is the mechanism of gold?
Suppresses phagocytosis by macrophages, suppresses antigen presentation and T cells
What is the mechanism of Azathioprine?
Blocks DNA synthesis primarily in T cells
What is the mechanism of cyclosporin?
Calcineurin inhibitor to inhibit T cell activation
What is the mechanism of Etanercept and Inflixumab
Blocks DNA TNF action
What is the mechanism of anakinra?
IL-1 receptor antagonist
What is the mechanism of abatacept?
Blocks T cell activation by antigen presenting cell (Binds CD80)
What is the mechanism of Ritixumab
Blocks B cell activation (Binds CD20)
What are the 4 options for RA treatment?
NSAIDs, Corticosteroids, Non-biological DMARDs, Biological DMARDs