Exam 3 inflammatory blistering diseases Flashcards
What are the hallmarks of HSV-1?
Above neck, mouth lesions, less recurrence than HSV-2
What are the hallmarks of HSV-2
genitalia STD, recurrent
What are the hallmarks of vericella (chicken pox)?
dew drops of a rose petal (chicken pox)
What are the hallmarks of herpes zoster?
Unilateral dermatome has many lesions
What are the hallmarks of impetigo?
honey-colored crusting
What are the hallmarks of bullous pemphigoid?
Tense blisters (don’t move much)
What is the disease associated with dermatitis herpetiformus?
celiac’s disease, gets worse with gluten
What is the hallmark of pemphigus vulgaris
flaccid blisters
What is the hallmark of porphyria cutanea tarda
hyperpigmentation
What do infections of HSV-1 and HSV-2 occur?
HSV-1 is in childhood, HSV2 is STD of adults
What is a specific treatment of HSV1
acycolvir (oral), famciclovir, valacyclovir, contagion prevention
How long does the varicella virus take to incubate?
14 days
What are the prodromes of varicella?
fever, chills, malaise, 2-3 days before onset of rash
What are major complications of varicella?
encephalitis, pneumonia, hepatitis, Reye’s syndrome, can become septic with secondary infections
What is the immunization schedule for varicella?
2 doses: 1st at 12-15 months then 2nd at 4-6 years. People over 13 years should get 2 doses 28 days apart
What is the prodrome of herpes zoster?
pain along nerve root up to 5 days prior to rash
What else should you rule out with herpes zoster?
Immunosuppression (cancer, HIV, connective tissue disease
What are the current treatments of herpes zoster?
acyclovir (PO, IV), prednisone
What should you worry about with a herpes zoster outbreak on the face?
Infection of the eye leading to blindness
How quickly should you treat herpes zoster to reduce post-herpetic neuralgia?
Treat within 48 hours
What causes non-bullous impetigo?
Group A strep pyogenese (catalase-, Beta hemolytic) staph aureus (catalase+, coagulase+), mixed infection
What causes bullous impetigo?
group II staph aureus (contains epidermolytic toxin)
What’s more common, bullous or non-bullous impetigo?
non-bullous
What is non-bullous impetigo?
single red macule or papule that becomes vesicle that erups and forms an erosion that dries to make honey-colored crust
What is bullous impetigo?
Superficial vesicles that progress rapidly to flaccid bullae with sharp margins and no surrounding erythema, eruption leads to yellow crust with oozing
Should you pop impetigo pustules?
NO
Treatment of bullous impetigo?
Hygienic measures, topical antibiotics, oral antibiotics
Name the different bullous diseases (all autoimmune)
Bullous pemphigoid, pemphigus vulgaris, dermatitis herpetiformis
Describe bullous pemphigoid. treatment?
Tensile bullae on normal or erythematous skin; prednisone, topical cortisone
Describe dermatitis herpetiformis. What disease is it associated with?
autoimmune condition with clusters of erythematous papules, pruritic and distributed symmetrically along extensor surfaces; Associated with Celiac’s
Describe pemphigus vulgaris
flaccid blisters on head, trunk and intertriginous areas, Nikoslky sign
What condition results in porphyria cutanea tarda?
deficiency in heme-synthesizing enzyme
Describe porphyria cutanea tarda?
blistering of skin in sun-exposed areas, hyperpigmentation
What are risk factors for porphyria cutanea tarda?
hepatitis C, hemochromatosis and alcoholism
