Exam 4 skin viral infections 2 Flashcards
What are the clinical presentations of HPV?
Acute: warts (penis, vulva, cervix, fingers, hands), Chronic: asymptomatic or carcinomas
What is the pathology of HPV?
transmitted by close contact, virus infections squamous basal cells, transforming to block p53 with viral protein E6, leading to benign growth
What is the diagnosis tool of HPV?
1% acetic acid turns lesions white, colposcopy + biopsy of white lesions, PCR using viral-specific primers
What is the treatment of HPV?
50% of warms regress within 2 years, Ablation, HPV vaccine
What is the clinical presentation of MCV?
pearly skin papules and nodules
What is the pathology of MCV?
Virus transmitted by casual contact and infects epidermal cells creating large eosinophilic inclusion bodies, these enlarge, rupture, become a crater
What is the diagnosis of MCV?
clinical presentation, skin biopsy (molluscum bodies)
Treatment of MCV?
Self resolves in 6-12 moths or surgically remove lesions
What is the clinical presentation of Smallpox?
rash (begins as macules, evolves to vesicles)
What is the pathology of smallpox?
2 routes of infection: 1: inhaled, virus infects respiratory mucosa, penetrates and enters blood stream, infection internal organs, release visions to infect skin (leading to focal lesions). 2: skin infected, particles collect and replicate in the epidermis forming merciless first in head then extremities, host immune response makes vesicles, crust forms and releases infectious particles
Diagnosis of smallpox
detection of vesicular fluid, serology
Treatment of smallpox
Vaccination
Clinical presentation of Orf virus?
Exanthemous disease causing denuded lesions
Pathology of Orf virus
Zoonotic disease, humans come into contact with infected sheep, virus causes local purulent-appearing papule with usually no systemic infections.
Diagnosis of Orf virus
Case history and clinical presentation
Treatment of Orf virus
1% topical cidofovir
Clinical presentation of Varicella zoster virus
Chicken pox or shingles
pathology of varicella/zoster virus
Contracted through respiratory secretions or contact with ruptured vesicles, infects respiratory tract, after 2 weeks it establishes viremia, flu like systems, dow on a rose petal, spreads centrifugally. Stops systemic, enters nerve roots
Diagnosis of varicella/zoster virus
Clinical aspect of the rash, multinucleate giants cells on Tzanck smear of skin lesions
Treatment of varicells/zoster
supportive, acyclovir or famciclovir for sever infections, Anti-VZV immunoglobulin, vaccines (live attenuated VZV)
What can be associated with aspirin treatment during chickenpox infection?
Reye’s sydrome, liver damage and encephelomyelitis
What is the clinical presentation of HSV 1
gingivostomatitis, keratoconjuctivis, herpes labialis, temporal lobe encephalitis
What is the pathology of HSV-1?
Virus is transmitted via saliva, invades mucous membranes leading to primary local infection, becoming latent in sensory ganglia
What is the diagnosis of HSV-1?
detection of virus, multinucleate giant cells on Tzanck smear, eosinophilic cowry intranuclear inclusion bodies on skin biopsy
Treatment of HSV-1?
acyclovir, trifluridine
Clinical presentation fo HSV-2?
genital herpes or neonatal herpes