Exam 4 parasite treatments

Question 1

Treatment of onchocerciasis and it’s action

Answer 1

Invermectin- targets glutamate-gated chloride channels

Question 2

Treatment of Leishmania

Answer 2

Sodium stibogluconate, meglamine antimoniate, miltefosine, liposomal amphoteracin B (Visceral-target ergosterol)

Question 3

Treatment of Chagas’ disease (T. cruzii)

Answer 3

Nifurtimox and Benznidazole- both target NAD(P)H-dependent dehydrogenase impairing mitochondria and inducing oxidative stress

Question 4

Treatment of African sleeping sickness and their actions

Answer 4

Suramin (inhibits PPP and glycolytic cycle), Pentamidine (targets DNA replication of mt), Eflornithine (inhibits ornithine decarboxylase), Melarsoprol

Question 5

Treatment of lymphatic filariasis

Answer 5

Diethylcarbamazine (DEC) targets the arachidonic acid metabolism cycle

Question 6

Treatment of Toxoplasmosis

Answer 6

Atovaquone, Sulfadiazine and Pyrimethamine (folate antagonists), Spiramycin (macrolide)