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PHARM > final: endocrin > Flashcards

final: endocrin Flashcards

1
Q

Oxytocin (pitocin) action

A

mimics oxytocin that naturally occurs in the body

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2
Q

Oxytocin (pitocin) use

A
  • induces or augments labor by increasing strength, frequency and length of uterine contractions
  • control of postpartum bleeding
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3
Q

Oxytocin (pitocin) SE

A
  • hyperstimulation (bad for baby)
  • uterine rupture
  • post delivery atony when used intrapartum (risk for bleeding)
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4
Q

caution for Oxytocin (pitocin)

A

potentiates hypersensitive effects of other drugs

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5
Q

dinoprostone (cervidil) class

A

synthetic prostaglandin

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6
Q

dinoprostone (cervidil) admin

A

inserted into vagina and placed near the cervix

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7
Q

dinoprostone (cervidil) use

A
  • ripens (softens) cervix

- induces contractions

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8
Q

dinoprostone (cervidil) SE

A
  • N/V
  • fever
  • uterine rupture
  • hyperstimulation
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9
Q

dinoprostone (cervidil) contraindications

A

previous c-section

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10
Q

Magnesium sulfate decreases…

A
  • uterine contraction
  • neuromuscular conduction
  • acetylcholine release
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11
Q

Magnesium sulfate causes

A

vasodialation

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12
Q

Magnesium sulfate use

A
  • premature onset of labor

- pre-eclampsia and eclampsia

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13
Q

Magnesium sulfate SE

A
  • CNS depression, heart and reflex depression
  • flushing, sweating, hypotension
  • flaccid paralysis
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14
Q

Magnesium sulfate contraindications:

A

additive effect with CNS depressants

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15
Q

Conjugated Estrogen (premarin) class

A

mimics hormone estrogen

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16
Q

Conjugated Estrogen (premarin) use

A

relieve vasomotor symptoms of menopause

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17
Q

warning with Conjugated Estrogen (premarin)

A
  • use shortest time possible

- if you have a uterus you must take progestin to prevent endometrial buildup that leads to endometrial cancer

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18
Q

Conjugated Estrogen (premarin) SE

A
  • GI
  • fluid retention
  • wt gain
  • depression
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19
Q

BBW with Conjugated Estrogen (premarin)

A

increased risks of thromboembolic events, stroke

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20
Q

causes dementia in postmenopausal women

A

Conjugated Estrogen (premarin)

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21
Q

Conjugated Estrogen (premarin) contraindications

A
  • liver disease
  • those at risk for above disorders
  • Hx of repro cancer
  • smoking
  • fibroids
  • undiagnosed vaginal bleeding
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22
Q

Conjugated Estrogen (premarin) interacts with

A
  • anticonvulsants
  • barbiturates
  • rifampin
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23
Q

Medroxyprogesterone acetate (provera, Depo-Provera) class

A

synthetic progestin that mimics naturally occurring hormone progesterone

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24
Q

Medroxyprogesterone acetate (provera, Depo-Provera) use

A

○ Decrease hyperplasia of uterine lining
○ Changes proliferative endometrium into secretory
○ Suppress pituitary hormones to inhibit ovulation (Depo Provera)

25
Q

Medroxyprogesterone acetate (provera, Depo-Provera) SE

A

○ Headache/ Migraines/ Depression/Vision changes/loss/Weight gain
○ Irregular vaginal bleeding
○ GI Upset with nausea and vomiting

26
Q

Medroxyprogesterone acetate (provera, Depo-Provera) BBW

A
  • increased risk of cardiac complications, thromboembolic events
  • bone loss with depo provera
27
Q

Medroxyprogesterone acetate (provera, Depo-Provera CI

A

○ CV disease
○ Hx of thromboembolic event or cerebral hemorrhage
○ renal disease (progestin metabolites excreted in urine)
○ hepatic disease (metabolism of progestin occurs in liver)

28
Q

conjugated estrogen-medroxyprogesterone (prempro) is a combo of what two drugs

A
  • conjugated estrogen (premarin)

- medroxyprogesterone acetate (provera)

29
Q

conjugated estrogen-medroxyprogesterone (prempro) was created for which women

A

those with intact uterus who need to take progestin with estrogen HRT to reduce endometrial hyperplasia and subsequent risks

30
Q

conjugated estrogen-medroxyprogesterone (prempro) risks

A

same risks as each med individually

31
Q

estradiol and norethrindrone (ortho-novum) is also called

A

“the pill”

32
Q

estradiol and norethrindrone (ortho-novum) class

A

synthetic estrogen and progestin used to suppress menstrual cycle

33
Q

estradiol and norethrindrone (ortho-novum) use

A
  • contraception
  • achne
  • PMDD
  • menstrual disorders
34
Q

estradiol and norethrindrone (ortho-novum) SE

A
  • N/V
  • thromboembolism/mi/stroke/cardiovascular
  • gallbladder disease
  • edema/wt gain/headache
35
Q

estradiol and norethrindrone (ortho-novum) CI

A
  • 35+ smoking
  • liver issues
  • reproductive cancers in family (breast)
  • clot Hx
  • migraine with aura
36
Q

estradiol and norethrindrone (ortho-novum) interactions

A
  • antibiotics
  • anticonvulsants
  • barbiturates
  • griseofulvin

these increase chance of pregnancy

37
Q

Alendronate (Fosamax) class

A

bisphosphonate

38
Q

Alendronate (Fosamax) use

A

osteoprosis

39
Q

Alendronate (Fosamax) MOA

A

suppresses osteoclasts:

-osteoclast are bone cells that absorb bone in the process of bone turnover

40
Q

Alendronate (Fosamax) SE

A

-esophagitis, dysphagia, esophageal ulcers
-headache
-muscle pain
-decreased serum calcium
-atypical femur fracture
osteonecrosis of the jaw

41
Q

Alendronate (Fosamax) admin

A

with FULL glass of WATER (not juice)

  • 30 min before breakfast or other drugs
  • stay upright 30 mins after to promote absorption and decrease gastric irritation
42
Q

Alendronate (Fosamax) contraindications

A

must be able to sit for 30 mins

-no renal impairment

43
Q

Alendronate (Fosamax) interactions

A

-no ASA, NSAIDS, Antacids and Ca+2 hours apart

44
Q

testosterone class

A

man made version of naturally occurring testosterone in the body

45
Q

testosterone use

A

-androgen deficiency

46
Q

testosterone SE

A

MASCULINE CHARACTERISTICS

  • acne
  • hairloss
  • headache
  • hypercalcemia
  • bitter taste, mouth irritation, gum tenderness
  • jaundice
  • edema
47
Q

testosterone contraindications

A
  • liver disease

- prostate issues

48
Q

Sildenafil (viagra) class

A

PDE 5 inhibitor

49
Q

Sildenafil (viagra) uses

A

enhances erection by increasing bf to penis

50
Q

Sildenafil (viagra) onset

A

20-60 minutes and lasts up to 4 hours

51
Q

Sildenafil (viagra) taken

A

once in a 24 hr period

52
Q

Sildenafil (viagra) SE

A 
○ Increased risk of hypotension
○ Headache
○ Facial flushing
○ Dyspepsia
○ nasal congestion
○ Dizziness
○ Permanent loss of vision (rare), loss of hearing (rare)
○ Priapism (Persistent and painful erection)
53
Q

Sildenafil (viagra) interactions

A
  • nitrated
  • alpha blockers
  • antifungals
  • erythromycin
  • antiviral
54
Q

Sildenafil (viagra) absorption is decreased by

A

fatty foods and booze

55
Q

Finasteride (Proscar) class

A

5 alpha reductase inhibitor

-anti-testosterone drug

56
Q

Finasteride (Proscar) use

A

-benign prostatic hyperplasia

shrinks prostate so urine can pass

57
Q

Finasteride (Proscar) SE

A
  • sexual dysfunction

- feminine characteristics enhanced in men

58
Q

Finasteride (Proscar) cautions

A
  • preggo women shouldn’t touch this med
  • children shouldn’t take
  • can not give blood while taking
59
Q

Finasteride (Proscar) interactions

A
  • testosterone
  • anticholinergics
  • saw palmetto (herbal)

PHARM (15 decks)

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