Final: antiseizure meds

Question 1

seizures equils

Answer 1

neurological electrical storms

Question 2

what do antiepileptic meds do what with seizures

Answer 2

calm the storm (depress CNS)

Question 3

why cant you stop anti seizure meds abruptly

Answer 3

risk of seizure or status epilepticus

Question 4

avoid what with all antiseizure meds

Answer 4

alcohol (a CNS depressant)

Question 5

antiseizure meds do what with BC

Answer 5

makes oral pills less effective

Question 6

preg category for anti seizures

Answer 6

D or X

Question 7

Phenytoin (Dilantin) MOA

Answer 7

selective inhibition of sodium channels

Question 8

Phenytoin (Dilantin) SE

Answer 8

• vision issues
• gingival hyperplasia (swollen gums)
• drowsiness and CNS depression

Question 9

those who take Phenytoin (Dilantin) need to have

Answer 9

good oral hygiene

Question 10

drug interactions with Phenytoin (Dilantin)

Answer 10

-oral contraceptives
-warfarin (coumadin)
-glucocorticoids
(also dont take with other CNS depressants)

Question 11

Carbamazepine (Tegretol) MOA

Answer 11

inhibit the influx of sodium through sodium channels

Question 12

Carbamazepine (Tegretol) use

Answer 12

anti seizure

Question 13

Phenytonin (dilantin) use

Answer 13

antiseizure

Question 14

Carbamazepine (Tegretol) SE

Answer 14

• visual disturbances
• decreased excretion of water (fluid retention)
• skin rash
• bbone marrow suppression

Question 15

S/S of bone marrow suppression

Answer 15

fatigue, bleeding, fever, chills

Question 16

skin rashs seen in Carbamazepine (Tegretol)

Answer 16

• epidermal necrolysis

- stevens-johnson syndrome

Question 17

cautions with Carbamazepine (Tegretol)

Answer 17

drinking grapefruit juice can increase plasma levels

Question 18

Carbamazepine (Tegretol) drug interactions

Answer 18

• phenytoin
• phenobarbital
• OC
• warfarin

Question 19

Valproic Acid (Depakote) MOA

Answer 19

suppress neuronal Na and Ca channels, increases GABA effects

Question 20

Valproic Acid (Depakote) uses

Answer 20

• seizure

- bipolar disorder

Question 21

Valproic Acid (Depakote) SE

Answer 21

• life threatening: hepatic failure and pancreatitis

- gi disturbances

Question 22

Valproic Acid (Depakote) class

Answer 22

antiseizure

Question 23

Gabapentin (Neurontin) class

Answer 23

antiseizure

Question 24

Gabapentin (Neurontin) used for

Answer 24

partial seizures

also clinically perscribed for neuropathic pain

Question 25

Gabapentin (Neurontin) SE

Answer 25

• well tolerated
• CNS: somnolence, dizziness, ataxia, fatigue, nystagmus
• peripheral edema

Question 26

what is status epilepticus

Answer 26

continuous series of tonic-clonic seizures

Question 27

goals of treatment for status epilepticus

Answer 27

• maintain ventilation
• terminate seizure
• correct hypoglycemia
• initiate or continue long term suppression of drugs

Question 28

“rescue” diazepam routes

Answer 28

• IV
• intranasal
• rectal
• IM

Question 29

Diazepam (Valium) class

Answer 29

benzodiazepine (same family as Xanax)

“rescue” antiseizure

Question 30

Diazepam (Valium) MOA

Answer 30

enhance inhibitory effects of GABA

Question 31

Diazepam (Valium) uses

Answer 31

• status epilepticus
• muscle relaxant
• anxiety

Question 32

Diazepam (Valium) SE

Answer 32

• CNS depression (check resps)

- serious adverse effect: cardiovascular collapse, bradycardia and hypotenion

Question 33

what to check when using Diazepam (Valium)

Answer 33

respirations because it is a CNS depressant