Final: antidepressants

Question 1

when must antidepressants be taken before relief of symptoms begin

Answer 1

2-4 weeks

Question 2

dont stop taking antid’s….

Answer 2

prematurely or once you feel better

Question 3

antidepressant discontinuation syndrome

Answer 3

stopping antid suddenly s/s:

• flu-like symptoms
• insomnia
• nausea
• dizziness
• hyperactivity

Question 4

how to stop antid’s

Answer 4

taper off gradually over 6-8 week period

Question 5

BBW for antid’s

Answer 5

may increase suicidal thoughts in children and adolescents

Question 6

if a pt seems to have antid discontinuation syndrome what might be happening

Answer 6

pt may have skipped a dose by accident

Question 7

Fluoxetine (prozac) class

Answer 7

SSRI

selective serotonin reuptake inhibitior

Question 8

Fluoxetine (prozac) MOA

Answer 8

blocks serotonin reuptake which increases serotonin availability for the body

Question 9

indications for Fluoxetine (prozac)

Answer 9

• depression
• anxiety
• OCD

Question 10

Fluoxetine (prozac) SE

Answer 10

• n/v
• anxiety
• insomnia
• diarrhea

Question 11

Fluoxetine (prozac) contraindications

Answer 11

life threatening interaction wit MAOI

must wait 2 weeks between use

Question 12

BBW for Fluoxetine (prozac)

Answer 12

suicidal ideation

Question 13

Venlafxine (effexor) class

Answer 13

SNRI

selective serotonin and norepi reuptake inhibitor

Question 14

Venlafxine (effexor) action

Answer 14

inhibits serotonin and norepi reuptake making more available for use

Question 15

Venlafxine (effexor) uses

Answer 15

• depression
• anxiety
• pain

Question 16

Venlafxine (effexor) SE

Answer 16

more than SSRI but much less than TCA and MAOI

Question 17

Amitriptyline (Elavil) class

Answer 17

TCA
tricyclic antidepressant

amitriptiline is a tricyclic antidepressant that elevates mood

Question 18

Amitriptyline (Elavil) use

Answer 18

depression

Question 19

Amitriptyline (Elavil) SE most common

Answer 19

• sedation
• orthostatic hypotension
• anticholinergic effects

Question 20

Amitriptyline (Elavil) SE most dangerous

Answer 20

cardiac tox

Question 21

danger with Amitriptyline (Elavil)

Answer 21

danger of overdose, limit use and never use in suicidal pts

Question 22

Phenelzine (Nardil) class

Answer 22

MAOI

monoamine oxidase inhibitor

Question 23

major thing with Phenelzine (Nardil)

Answer 23

high incidnece of drug-drug and drug-food interactions so rarely given unless treatment resistant depression

Question 24

Phenelzine (Nardil) MOA

Answer 24

block MAO in brain making norepi and serotonin avilable

Question 25

Phenelzine (Nardil) use

Answer 25

depression and OCD

Question 26

Phenelzine (Nardil) SE

Answer 26

• orthostatic hypotension
• CNS stimulation
• Hypertensive crisis from dietary tyramine

Question 27

Phenelzine (Nardil) contraindications

Answer 27

avoid tyramine rich foods (chessses, cured meats, red wine, bananas) and many drug interactions