E3: Heart drugs Flashcards

1
Q

propranolol drug class

A

beta blocker

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2
Q

how does propranolol work

A

blocks beta adrenergic receptors of the sympathetic nervous system
(slows heart rate)

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3
Q

big effect for propranolol

A

slows heart rate!

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4
Q

what is propranolol used for (5)

A
  1. hypertension
  2. heart failure
  3. post MI
  4. angina
  5. arrhythmias
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5
Q

side effect of propranolol

A
  • depression
  • hypoglycemia
  • importance
  • dizziness
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6
Q

because propranolol is a nonselective beta blocker, what can happen

A

have effect on B2(lungs)

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7
Q

who is propranolol contraindicated in

A

people with asthma or other lung disorders

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8
Q

what do you need to check before admin of propranolol

A

make sure pulse is 60 or greater

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9
Q

captopril (capoten) cass

A

ACE inhibitor

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10
Q

what is the action of captopril (capoten)

A

block conversion of angiotensin I to angiotensin II which relaxes vessels and reduces reabsorption of fluid (reducing after load)

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11
Q

captopril (capoten) used for

A
  • HTN
  • heart failure
  • MI
  • Diabetic Nephropathy
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12
Q

most common side effect of captopril (capoten)

A

unrelenting cough

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13
Q

life threatening side effect of captopril (capoten)

A

angioedema

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14
Q

other side effects of captopril (capoten) (6)

A
  • Hyperkalemia
  • renal failure
  • GI distress
  • Rash
  • Neutropenia
  • agranulocytosis
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15
Q

what drug does captopril (capoten) interact with

A

Digoxin (raises digoxin levels)

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16
Q

captopril (capoten) is contraindicated in who

A

pregnant people

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17
Q

when to take captopril (capoten)

A

one hour before meals and two hrs apart from antacids

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18
Q

Losartan (Cozaar) class

A

angiotensin II receptor blockers (ARB)

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19
Q

action of Losartan (Cozaar)

A

block angiotensin II causing vasodialatio, reduces volume

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20
Q

SE for Losartan (Cozaar)

A
  • Hyperkalemia
  • renal failure
  • GI distress
  • Rash
  • Neutropenia
  • agranulocytosis
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21
Q

contraindication for Losartan (Cozaar)

A

Do not take during pregnancy

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22
Q

when to take Losartan (Cozaar)

A

may take with food

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23
Q

Verapamil (Calan) class

A

calcium channel blocker

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24
Q

Verapamil (Calan) action

A

blocks calcium from cardiac cell reducing contraction, causing vasodialation

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25
Q

Verapamil (Calan) uses (4)

A
  • HTN
  • Angina
  • Arrhythmias
  • circulatory conditions
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26
Q

SE of Verapamil (Calan) (3)

A
  • peripheral edema
  • constipation
  • suppression of cardiac function (heart block, dysrhy, HF)
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27
Q

Verapamil (Calan) interacts with

A

grapefruit juice and beta blockers

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28
Q

Nifedipine (Procardia) class

A

calcium channel blocker

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29
Q

Nifedipine (Procardia) action

A

blocks calcium from cardiac cell reducing contraction causing vasodialation

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30
Q

Nifedipine (Procardia) uses (4)

A
  • HTN
  • angina
  • arrhythmias
  • circulatory conditions
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31
Q

Nifedipine (Procardia) SE

A
  • peripheral edema

- constipation

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32
Q

Nifedipine (Procardia) interacts with what

A
  • grapefruit

- increased hypotension with beta blockers

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33
Q

Hydralazine (Apresoline) action

A

direct vasodialation of veins and arteries causing rapid drop in BP

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34
Q

Hydralazine (Apresoline) uses

A
  • severe HTN

- heart failure

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35
Q

Hydralazine (Apresoline) SE (5)

A
  • headache
  • dizziness
  • edema
  • chest apin
  • reflex tachy
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36
Q

monitor what with Hydralazine (Apresoline)

A

BP carefully

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37
Q

Sodium Nitroprusside (Nitropress) action

A

direct vasodialation of veins and arteries causing rapid drop in BP

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38
Q

Sodium Nitroprusside (Nitropress) uses

A

hypertensie emergency

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39
Q

risk with Sodium Nitroprusside (Nitropress)

A

risk of cyanide toxicity

those with liver disorders at an increased risk

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40
Q

Sodium Nitroprusside (Nitropress) SE (5)

A
  • headache
  • dizziness
  • edema
  • chest pain
  • reflex tachy
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41
Q

Sodium Nitroprusside (Nitropress) admin

A

do not admin in a line with any other medication (needs own line)

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42
Q

monitor what with Sodium Nitroprusside (Nitropress)

A

close cardiac monitoring

43
Q

Digoxin (Lanoxin) class

A

cardiac glycoside

44
Q

Digoxin (Lanoxin) action

A

increases the level of calcium inside the cell by inhibiting the sodium-potassium pump

45
Q

Digoxin (Lanoxin) uses

A
  • heart failure

- arrhythmias (A-fib)

46
Q

SE of Digoxin (Lanoxin)

A
  • HA
  • seizures
  • drowsiness
  • arrhhythmias
47
Q

therapeutic levels for Digoxin (Lanoxin)

A

.5-2.0 ng/ml

48
Q

if admin Digoxin (Lanoxin) iv infuse over

A

5 minutes at least

49
Q

what to check for Digoxin (Lanoxin)

A

pulse

less than 60, contract provider

50
Q

what are the s/s of Digoxin (Lanoxin) toxicity

A
  • yellow halos
  • confusion
  • N/V
  • cardiac disturbances
51
Q

what does Digoxin (Lanoxin) interact with

A
  • electrolyte disturbance

- hypokalemia with potassium wasting diuretics

52
Q

Dopamine (Intropin) class

A

catecholamine (same fam as epi)

53
Q

Dopamine (Intropin) uses

A
  • heart failure
  • shock

(EMERGENCY drug)

54
Q

SE of Dopamine (Intropin)

A
  • necrosis when solution extravastes
  • dysrhythmias
  • angina
55
Q

low dose Dopamine (Intropin)

A

renal vasodialation

“renal dose)

56
Q

mod dose Dopamine (Intropin)

A

renal dose + increase HR, contractility, AV conduction

57
Q

high dose Dopamine (Intropin)

A

renal dose + increase HR, contractility, AV conduction + VASOCONSTRICTION

58
Q

what to monitor with Dopamine (Intropin)

A

continuous cardiac monitoring

59
Q

Hydrochlorothiazide class

A

thiazide diuretic

60
Q

Hydrochlorothiazide action

A

prootes urine production by blocking the reabsorption of sodium and chloride in the early segment of the distal convoluted tubule

61
Q

Hydrochlorothiazide uses

A
  • HTN

- edema

62
Q

SE of Hydrochlorothiazide

A
  • dehydration

- electrolyte imbalances

63
Q

Hydrochlorothiazide interacts with what

A

digoxin

64
Q

Furosemide (Lasix) action

A

inhibits chloride reabsorption in ascending loop of henle

65
Q

what is a problem with Furosemide (Lasix)

A

high loss of K in urine

66
Q

Furosemide (Lasix) (4)

A
  • HTN
  • hypertensive emergencies
  • edema
  • pulmonary edema
67
Q

SE of Furosemide (Lasix)

A
  • dehydration
  • electrolyte imbalances
  • ototoxicity
68
Q

Furosemide (Lasix) interacts with what

A

digoxin (hyperkalemia)

69
Q

Spironolactone (Aldactone) classeS

A
  • aldosterone antagonists

- potassium sparing diuretic

70
Q

Spironolactone (Aldactone) action

A

reduces blood volume by blocking aldosterone receptors in kidney and increases excretion of sodium and water

71
Q

Spironolactone (Aldactone) uses

A
  • HTN

- heart failure

72
Q

SE of Spironolactone (Aldactone) (4)

A
  • hyperkalemia
  • hyponatremia
  • flu like symptoms
  • dizziness
73
Q

Lidocaine (Xylocaine) use

A

use only for VENTRICULAR dysrhythmias in hospital

74
Q

SE of Lidocaine (Xylocaine) (3)

A
  • respiratory arrest
  • seizures
  • fatigue
75
Q

how is Lidocaine (Xylocaine) dosed

A

started with high loading dose and lower maintenance dose

76
Q

Amiodarone (Cordarone) class

A

potassium channel blockers

77
Q

Amiodarone (Cordarone) action

A

decreases conduction, automaticity, repolarization rate and contractility

78
Q

Amiodarone (Cordarone) uses

A
  • recurrent A fib
  • V fib
  • V tach
79
Q

SE of Amiodarone (Cordarone)

A

MANY

-major SE is pulmonary toxicity

80
Q

Amiodarone (Cordarone) interacts with

A

grapefruit and many cardiac drugs

81
Q

Amiodarone (Cordarone) has a long what

A

half life- interactions can take place even after cessation of drug

82
Q

Adenosine (Adenocard) class

A

endogenous glucoside

83
Q

Adenosine (Adenocard) action

A

decreased conduction through the AV node

84
Q

Adenosine (Adenocard) use

A
  • antiarrhythmic

- paroxysmal SVT

85
Q

Adenosine (Adenocard) speed

A

FAST

short half life

86
Q

how to admin Adenosine (Adenocard)

A

quick IV push with quick saline flush

87
Q

after admin what might happen

A

may be short moment of asystole before normal rhythm begins

88
Q

Adenosine (Adenocard) is contraindicated in (3)

A
  • a-fib
  • a-flutter
  • heart block
89
Q

Lovastatin (Mevacor) class

A

HMG-CoA reductase inhibitor

90
Q

Lovastatin (Mevacor) ation

A

inhibits HMG CoA reductase in liver limiting cholesterol synthesis

91
Q

Lovastatin (Mevacor) decreases

A
  • cholesterol
  • LDL
  • VLDL
  • triglycerides
92
Q

Lovastatin (Mevacor) increases

A

HDL

93
Q

SE of Lovastatin (Mevacor) (6)

A
  • GI distress
  • Headache
  • Myalgia (muscle soreness)
  • rhabdomyolysis (muscle wasting
  • weakness
  • ocular and liver toxicity
94
Q

when do results appear with Lovastatin (Mevacor)

A

6-12 months

95
Q

when to take Lovastatin (Mevacor)

A

evening meal

96
Q

Lovastatin (Mevacor) is contraindicated in

A

pregnancy and in those with liver problems

97
Q

Nitroglycerin (Nitrostat) class

A

organic nitrate

98
Q

angina=

A

need for O2

99
Q

Nitroglycerin (Nitrostat) action

A

nicto decreases cardiac O2 demand by dilating veing and decreasing venous return (preload)

relaxes coronary arteries increasing o2 supply

100
Q

has a significant first pass effect

A

Nitroglycerin (Nitrostat)

101
Q

Nitroglycerin (Nitrostat) admin

A

sublingual

take with pain, wait 5, call 911 and take another, take 3rd in another 5

102
Q

do not take with Nitroglycerin (Nitrostat)

A

viagra or booze

103
Q

SE of V

A
  • headache

- reflex tachy