E3: blood drugs Flashcards

1
Q

Heparin class

A

anticoagulant

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2
Q

Heparin goal

A

prevent clot or progression of clot

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3
Q

Heparin action

A

prevent clotting by activating antithrombin thus inactivating thrombin and factor Xa (inhibits fibrin formation)

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4
Q

Heparin admin

A

not absorbed in the GI

must be given subq or iv infusion

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5
Q

how often are labs done with Heparin

A

daily to monitor coagulation effects (aPPT)

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6
Q

antidote for Heparin

A

protamine sulfate

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7
Q

risk with Heparin

A

risk for bleeding and life threatening heparin induced thrombocytopenia

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8
Q

Enoxaparin (Lovenox) class

A

anticoagulant

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9
Q

Enoxaparin (Lovenox) goal

A

prevent clot or progression of clot

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10
Q

why is Enoxaparin (Lovenox) different than heparin

A

more predictable anticog response than heparin

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11
Q

Enoxaparin (Lovenox) action

A

Prevent clotting by activating antithrombin, thus indirectly inactivating both
thrombin and factor Xa. This inhibits fibrin formation.

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12
Q

Enoxaparin (Lovenox) antidote

A

protamine sulfate

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13
Q

labs with Enoxaparin (Lovenox)

A

does not require lab monitoring

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14
Q

Enoxaparin (Lovenox) admin

A

Not absorbed by the intestinal tract and must be given by subcutaneous
injection or IV infusion.

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15
Q

Warfarin (Coumadin) class

A

anticoag

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16
Q

Warfarin (Coumadin) goal

A

prevent clot or progression of clot

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17
Q

Warfarin (Coumadin) action

A

antagonizes vitamin K therefor preventing synthesis of four coag factors

18
Q

antidote to Warfarin (Coumadin)

19
Q

how is Warfarin (Coumadin) monitored

A

by prothrombin time (PT) and INR

20
Q

avoid food with K that may decrease antigoag effects of what

A

Warfarin (Coumadin)

21
Q

Dabigatran (Pradaxa) class

A

direct thrombin inhibitor

anticoag

22
Q

Dabigatran (Pradaxa) goal

A

prevent clot or progression of clot

23
Q

Dabigatran (Pradaxa) antidote

24
Q

monitoring for Dabigatran (Pradaxa)

A

no monitoring

25
Rivaroxaban (Xarelto) class
anticoag direct factor Xa inhibitor
26
Rivaroxaban (Xarelto) goal
prevent clot or progression of clot
27
Rivaroxaban (Xarelto) monitoring
no monitoring required | liver function monitoring
28
Rivaroxaban (Xarelto) antidote
no antidote
29
Aspirin class
antiplatelet
30
Aspirin goal
prevent initial clot formation
31
Aspirin action
blocks thromboxane resulting in slippery platelet that wont aggregate
32
once platelet is bound to ASA is is irreversiblely bound
know this
33
SE of Aspirin
- tinnitus | - GI side effects common
34
Clopidogrel (Plavix) class
anti platelet
35
Clopidogrel (Plavix) goal
prevent initial clot formation
36
Clopidogrel (Plavix) binding is
irreversible
37
Clopidogrel (Plavix) action
Blocks the adenosine diphosphate (ADP) receptor on the platelet membrane, preventing the platelet from “connecting” with other platelets.
38
Alteplase (Activase) class
thrombolytic or fibrinolytic
39
Alteplase (Activase) goal
eliminate formed clots
40
Alteplase (Activase) action
Binds to fibrin in the thrombus, converting entrapped plasminogen to plasmin, initiating local fibrinolysis
41
Alteplase (Activase) uses
- Stroke - Mi - suspected occlusion
42
risk with Alteplase (Activase)
severe risk for bleeding (hemorrhage)