E3: blood drugs Flashcards
Heparin class
anticoagulant
Heparin goal
prevent clot or progression of clot
Heparin action
prevent clotting by activating antithrombin thus inactivating thrombin and factor Xa (inhibits fibrin formation)
Heparin admin
not absorbed in the GI
must be given subq or iv infusion
how often are labs done with Heparin
daily to monitor coagulation effects (aPPT)
antidote for Heparin
protamine sulfate
risk with Heparin
risk for bleeding and life threatening heparin induced thrombocytopenia
Enoxaparin (Lovenox) class
anticoagulant
Enoxaparin (Lovenox) goal
prevent clot or progression of clot
why is Enoxaparin (Lovenox) different than heparin
more predictable anticog response than heparin
Enoxaparin (Lovenox) action
Prevent clotting by activating antithrombin, thus indirectly inactivating both
thrombin and factor Xa. This inhibits fibrin formation.
Enoxaparin (Lovenox) antidote
protamine sulfate
labs with Enoxaparin (Lovenox)
does not require lab monitoring
Enoxaparin (Lovenox) admin
Not absorbed by the intestinal tract and must be given by subcutaneous
injection or IV infusion.
Warfarin (Coumadin) class
anticoag
Warfarin (Coumadin) goal
prevent clot or progression of clot
Warfarin (Coumadin) action
antagonizes vitamin K therefor preventing synthesis of four coag factors
antidote to Warfarin (Coumadin)
vitamin K
how is Warfarin (Coumadin) monitored
by prothrombin time (PT) and INR
avoid food with K that may decrease antigoag effects of what
Warfarin (Coumadin)
Dabigatran (Pradaxa) class
direct thrombin inhibitor
anticoag
Dabigatran (Pradaxa) goal
prevent clot or progression of clot
Dabigatran (Pradaxa) antidote
praxibind
monitoring for Dabigatran (Pradaxa)
no monitoring