E2 endocrin Flashcards
propylthiouracil (PTU) class
anti-thyroid, thionamide
how does propylthiouracil (PTU) work
supresses synthesis of thyroid hormone in hyperthyroidism
propylthiouracil (PTU) dose is dependent on what
metabolism, as thyroid gets under control, less drug is needed
propylthiouracil (PTU) can be what (used)
used alone or with other therapies
propylthiouracil (PTU) is good for who
children who have greater risks with radioactive iodine
propylthiouracil (PTU) is not preferred for who
older adults
BBW for propylthiouracil (PTU)
severe liver injury resulting in death or acute liver failure
propylthiouracil (PTU) adverse effects
- hypothyrodism
- agranulocytosis-
- derma effects
- CNS effects
- GI effects
levothyroxine use
choice drug for long term treatment of hypothyroidism
levothyroxine is what kind of therapy
life long with medical supervision needed
you cannot just stop levothyroxine abruptly
duh
adverse effects with levothyroxine
- s/s of hyperthyroidism
- tachy
- dys
- fractures from bone loss
dosage with levothyroxine needs to be what
individualized
when to take levothyroxine and what before
on empty stomach in the AM and take pulse before
what to watch for with levothyroxine
thyroidtoxicosis
somatropin use
used in kids whos growth is impaired by deficiency of endrogenous GH
how does somatropin work
stimulates skeletal, linear, muscle, organ grown
how is somatropin given
SQ or IM
adverse effects of somatropin
not common
-fewer in kids
somatropin decreases what
insulin sensitivity resulting in hyperglycemia
somatropin interacts with what
glucocorticoids (dont take at same time)
desmopressin (DDAVP) class
posterior pituitary hormone
desmopressin (DDAVP) use
diabetes insipidus
how is desmopressin (DDAVP) given
oral, intranasal, IV
what is a big contraindication with desmopressin (DDAVP)
creatinine clearance of less than 50
what do you need to asses with desmopressin (DDAVP)
sodium levels and decreased mental status or seizure activity
bbw with desmopressin (DDAVP)
- hyponatremia may develope and lead to seizures
2. changes in fluid volume status may result in cardiac arrest in client with known cardiovascular disease
hydrocortisone class
glucocorticoid
hydrocortisone use
in acute and chronic adrenal insufficiency such as addison’s
older individuals taking hydrocortisone need what kind of dose
lower dose
bbw for hydrocortisone
clients should not recieve live virus vaccs with taking hydrocortisone
what kind of therapy is hydrocortisone
lifelong
when to take hydrocortisone
by 9 am each day to prevent HPA supression
do not stop taking abruptly with this drug
hydrocortisone
at times of stress, you need to increase dose with which drug
hydrocortisone
ketoconazole (nizoral) class
antifungal drug that also blocks glucocorticoid cynthesis
ketoconazole (nizoral) use
therapy for cushing’s (too much cortisol)
how does ketoconazole (nizoral) work
inhibits enzyme contained in cortisol synthesis
bbw with ketoconazole (nizoral)
may cause hepatotoxicity
what enhances ketoconazole (nizoral) absorption
acidic drinks
what do you need to monitor when taking ketoconazole (nizoral)
liver enzymes
