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PHARM > E2 endocrin > Flashcards

E2 endocrin Flashcards

1
Q

propylthiouracil (PTU) class

A

anti-thyroid, thionamide

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2
Q

how does propylthiouracil (PTU) work

A

supresses synthesis of thyroid hormone in hyperthyroidism

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3
Q

propylthiouracil (PTU) dose is dependent on what

A

metabolism, as thyroid gets under control, less drug is needed

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4
Q

propylthiouracil (PTU) can be what (used)

A

used alone or with other therapies

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5
Q

propylthiouracil (PTU) is good for who

A

children who have greater risks with radioactive iodine

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6
Q

propylthiouracil (PTU) is not preferred for who

A

older adults

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7
Q

BBW for propylthiouracil (PTU)

A

severe liver injury resulting in death or acute liver failure

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8
Q

propylthiouracil (PTU) adverse effects

A
  • hypothyrodism
  • agranulocytosis-
  • derma effects
  • CNS effects
  • GI effects
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9
Q

levothyroxine use

A

choice drug for long term treatment of hypothyroidism

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10
Q

levothyroxine is what kind of therapy

A

life long with medical supervision needed

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11
Q

you cannot just stop levothyroxine abruptly

A

duh

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12
Q

adverse effects with levothyroxine

A
  • s/s of hyperthyroidism
  • tachy
  • dys
  • fractures from bone loss
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13
Q

dosage with levothyroxine needs to be what

A

individualized

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14
Q

when to take levothyroxine and what before

A

on empty stomach in the AM and take pulse before

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15
Q

what to watch for with levothyroxine

A

thyroidtoxicosis

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16
Q

somatropin use

A

used in kids whos growth is impaired by deficiency of endrogenous GH

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17
Q

how does somatropin work

A

stimulates skeletal, linear, muscle, organ grown

18
Q

how is somatropin given

A

SQ or IM

19
Q

adverse effects of somatropin

A

not common

-fewer in kids

20
Q

somatropin decreases what

A

insulin sensitivity resulting in hyperglycemia

21
Q

somatropin interacts with what

A

glucocorticoids (dont take at same time)

22
Q

desmopressin (DDAVP) class

A

posterior pituitary hormone

23
Q

desmopressin (DDAVP) use

A

diabetes insipidus

24
Q

how is desmopressin (DDAVP) given

A

oral, intranasal, IV

25
Q

what is a big contraindication with desmopressin (DDAVP)

A

creatinine clearance of less than 50

26
Q

what do you need to asses with desmopressin (DDAVP)

A

sodium levels and decreased mental status or seizure activity

27
Q

bbw with desmopressin (DDAVP)

A
  1. hyponatremia may develope and lead to seizures

2. changes in fluid volume status may result in cardiac arrest in client with known cardiovascular disease

28
Q

hydrocortisone class

A

glucocorticoid

29
Q

hydrocortisone use

A

in acute and chronic adrenal insufficiency such as addison’s

30
Q

older individuals taking hydrocortisone need what kind of dose

A

lower dose

31
Q

bbw for hydrocortisone

A

clients should not recieve live virus vaccs with taking hydrocortisone

32
Q

what kind of therapy is hydrocortisone

A

lifelong

33
Q

when to take hydrocortisone

A

by 9 am each day to prevent HPA supression

34
Q

do not stop taking abruptly with this drug

A

hydrocortisone

35
Q

at times of stress, you need to increase dose with which drug

A

hydrocortisone

36
Q

ketoconazole (nizoral) class

A

antifungal drug that also blocks glucocorticoid cynthesis

37
Q

ketoconazole (nizoral) use

A

therapy for cushing’s (too much cortisol)

38
Q

how does ketoconazole (nizoral) work

A

inhibits enzyme contained in cortisol synthesis

39
Q

bbw with ketoconazole (nizoral)

A

may cause hepatotoxicity

40
Q

what enhances ketoconazole (nizoral) absorption

A

acidic drinks

41
Q

what do you need to monitor when taking ketoconazole (nizoral)

A

liver enzymes

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