Fetal Medicine Flashcards
Describe Apgar score parameters?
A score of 0-3 is very low score, between 4-6 is moderate low and between 7 - 10 means the baby is in a good state
Apgar score components include?
Pulse Respiratory effort Colour Muscle tone Reflex irritability
A score of 0 in the agpar score parameters is?
Absent pulse No resp effort Blue all over Flaccid No reflex irritability
A score of 1 in the agpar score parameters is?
< 100 pulse
Resp effort weak & irregular
Body pink, extremities blue
Limb flexion Grimace
A score of 2 in the agpar score parameters is?
> 100 pulse resp effort Strong, crying Pink baby Muscle tone - Active movement Cries on stimulation/sneezes, coughs
Normal term babies often have hypoglycaemia especially in the first 24 hrs of life
true
Normal term babies often have hypoglycaemia without sequalae due to
they can utilise alternate fuels like ketones and lactate
There is no agreed definition of neonatal hypoglycaemia but a figure of < 2.6 mmol/L is used in many guidelines.
true
Transient hypoglycaemia in the first hours after birth is common.
true
Persistent/severe hypoglycaemia may be caused by:
preterm birth (< 37 weeks) maternal diabetes mellitus IUGR hypothermia neonatal sepsis inborn errors of metabolism nesidioblastosis Beckwith-Wiedemann syndrome
Neonatal hypoglycaemia leads to hypo/hyperthermia
hypothermia
Neonatal hypoglycaemia symptoms - autonomic (hypoglycaemia → changes in neural sympathetic discharge)
‘jitteriness’
irritable
tachypnoea
pallor
Neonatal hypoglycaemia symptoms - neuroglycopenic
poor feeding/sucking weak cry drowsy hypotonia seizures
Management of neonatal hypoglycaemia depends on
severity of the hypoglycaemia and if the newborn is symptomatic
Management of neonatal hypoglycaemia - asymptomatic
encourage normal feeding (breast or bottle)
monitor blood glucose
Management of neonatal hypoglycaemia - symptomatic or very low blood glucose
admit to the neonatal unit
intravenous infusion of 10% dextrose
Causes of neonatal hypotonia include:
neonatal sepsis
Werdnig-Hoffman disease (spinal muscular atrophy type 1)
hypothyroidism
Prader-Willi
Causes of maternal hypotonia include:
maternal drugs e.g. benzodiazepines
maternal myasthenia gravis
Neonatal sepsis occurs when a serious bacterial or viral infection in the blood affects babies within the first ? days of life.
28
Neonatal sepsis is categorised into early-onset and late-onset
- define
(EOS, within 72 hours of birth)
LOS, between 7-28 days of life
Neonatal sepsis account for 10% of all neonatal mortality
true
Black race is an independent risk factor for group B streptococcus-related sepsis
true
The overall most common causes of neonatal sepsis are ?, accounting for approximately two thirds of neonatal sepsis cases
The overall most common causes of neonatal sepsis are group B streptococcus (GBS) and Escherichia coli, accounting for approximately two thirds of neonatal sepsis cases
Early-onset sepsis in the UK is primarily caused by
Early-onset sepsis in the UK is primarily caused by GBS infection (75%)
Late-onset sepsis usually occurs via the transmission of pathogens from the environment post-delivery, this is normally from contacts such as the parents or healthcare workers
Infective causes are more commonly
coagulase-negative staphylococcal species such as Staphylococcus epidermidis, Gram-negative bacteria such as Pseudomonas aeruginosa, Klebsiella and Enterobacter, and fungal species
Risk factors of neonatal sepsis
Mother who has had a previous baby with GBS infection, who has current GBS colonisation from prenatal screening, current bacteruria, intrapartum temperature ≥38ºC, membrane rupture ≥18 hours, or current infection throughout pregnancy
premature
low birth weight
,aternal chorioamnionitis
Neonatal sepsis - Patients typically present with a subacute onset of what most commonly?
Respiratory distress (85%) Grunting Nasal flaring Use of accessory respiratory muscles Tachypnoea
Temperature is not usually a reliable sign as the temperature can vary from being raised, lowered or normal for neontal sepsis
Term infants are more likely to be ?
Pre-term infants are more likely to be ?
Term infants are more likely to be febrile
Pre-term infants are more likely to be hypothermic
Neonatal sepsis ix wht will usually establish the diagnosis
Blood culture
sepsis - in neonates, parameters on full blood examination are usually not always useful for diagnosis, rather may help to exclude healthy neonates
true
neonatal sepsis - what will sequential assessment will help to guide management and patient progress with treatment
crp
metabolic acidosis is particularly concerning for neonatal sepsis, particularly a base deficit of ≥10 mmol/L
true
first-line regimen for suspected or confirmed neonatal sepsis
intravenous benzylpenicillin with gentamicin
Neonatal Sepsis - Other important management factors to consider include
Maintaining adequate oxygenation status
Maintaining normal fluid and electrolyte status
Prevention and/or management of hypoglycaemia
Prevention and/or management of metabolic acidosis
Jaundice in the first 24 hrs is normal
false
always pathological
Causes of jaundice in the first 24 hrs
rhesus haemolytic disease
ABO haemolytic disease
hereditary spherocytosis
glucose-6-phosphodehydrogenase
Jaundice in the neonate from the c. 2-14 days is common (up to 40%) and usually physiological.
true
Jaundice in the neonate from the c. 2-14 days is common (up to 40%) and usually physiological. is most commonly seen in which babies
breastfed
If there are still signs of jaundice after 14 days a prolonged jaundice screen is performed, including:
conjugated and unconjugated bilirubin direct antiglobulin test (Coombs' test) TFTs FBC and blood film urine for MC&S and reducing sugars U&Es and LFTs
Causes of prolonged jaundice
biliary atresia hypothyroidism galactosaemia urinary tract infection breast milk jaundice congenital infections e.g. CMV, toxoplasmosis
Newborn resuscitation - first thing to do?
- Dry baby and maintain temperature
- Assess tone, respiratory rate, heart rate
- If gasping or not breathing give 5 inflation breaths
- Reassess (chest movements)
- If the heart rate is not improving and <60bpm start compressions and ventilation breaths at a rate of 3:1
Peripheral cyanosis, for example of the feet and hands, is very common in the first 24 hours of life and may occur when the child is crying or unwell from any cause
true