Antiplatelets/Anticoagulants/Thrombolysis Flashcards
hree direct oral anticoagulants (DOACs)
dabigatran, rivaroxaban and apixaban.
Direct factor Xa inhibitor examples
Rivaroxaban Apixaban
Direct thrombin inhibitor examples
Dabigatran
Excretion of DOACs
Majority renal - Dabigatran
Majority liver - Rivaroxaban
Majority faecal - apixaban
Direct factor Xa inhibitor revesal agents
Andexanet alfa
Direct thrombin inhibitor reversal agents
Idarucizumab
Clopidogrel is an anticoagulant/antiplatelet agent
Clopidogrel is an antiplatelet agent
Clopidogrel belongs to a class of drugs known as
thienopyridines
thienopyridines examples
Clopidogrel
prasugrel
ticagrelor
ticlopidine
Clopidogrel mechanism of action?
antagonist of the P2Y12 adenosine diphosphate (ADP) receptor, inhibiting the activation of platelets
Clopidogrel interactions
concurrent use of proton pump inhibitors (PPIs) may make clopidogrel less effective
Aspirin works by
blocking the action of both cyclooxygenase-1 and 2
Cyclooxygenase is responsible for
prostaglandin, prostacyclin and thromboxane synthesis.
The blocking of thromboxane A2 formation in platelets reduces the ability of platelets to aggregate which has lead to the widespread use of low-dose aspirin in cardiovascular disease.
Aspirin potentiates?
oral hypoglycaemics
warfarin
steroids
Aspirin should not be used in children under 16 due to
risk of Reye’s syndrome
An exception is Kawasaki disease, where the benefits are thought to outweigh the risks.
NICE now recommend what first-line following an ischaemic stroke and for peripheral arterial disease.
NICE now recommend clopidogrel first-line following an ischaemic stroke and for peripheral arterial disease.
first-line for patients with ischaemic heart disease
aspirin
Heparins generally act by
activating antithrombin III.
? forms a complex which inhibits thrombin, factors Xa, IXa, XIa and XIIa.
? however only increases the action of antithrombin III on factor Xa
Unfractionated heparin forms a complex which inhibits thrombin, factors Xa, IXa, XIa and XIIa.
LMWH however only increases the action of antithrombin III on factor Xa
Adverse effects of heparins include:
bleeding
thrombocytopenia
osteoporosis