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Bloc E - GI & Metabolism > Feb19 M2-Intestinal Motor Function > Flashcards

Feb19 M2-Intestinal Motor Function Flashcards

1
Q

SI motor activity

A
  • effective mixing

- slow propulsion

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2
Q

BER in SI charact (electrical control activity)

A
  • f fixed for certain region
  • origin is ICCs*****
  • DOESN’T CAUSE contractions
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3
Q

ERA charact

A
  • triggered by stretch or Ca
  • spikes freq on BER plateau. proportional to magnitude of stimuus
  • max freq is max freq of BER
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4
Q

how action potentials travel in SI (and stomach)

A

gap-junctions (ICCs and muscle fibers)

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5
Q

intrinsinc freq of BER in diff SI regions and colon

A

duod: 12 per min
jejunum: 10.5-12
ileum: 10.5
colon: 4-6 per min

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6
Q

proximal vs distal SI peristalsis

A
  • f of BER higher
  • SM more excitable
  • thicker SM
  • frequency and amplitude of contractions greater in proximal SI
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7
Q

(EXAM) 2 types of contractions in SI

A

segmentation and peristalsis

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8
Q

segmentation def + why exists

A

rings of circular contraction. to slow down and mix (bouncing back)

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9
Q

peristalsis def

A

1 propagating circulating ring.

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10
Q

segmentation charact

A
  • stimulus is DISTENSION (not automatic)
  • CIRCULAR only
  • ANS, hormones and ENS modul long distance
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11
Q

segmentation what exactly modulates it (what structure)

A

Auerbach’s plexus

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12
Q

consequence of issue in segmentation

A

diarrhea (bc segmentation offers resistance)

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13
Q

peristalsis charact (+ how differs from segmentation)

A
  • infrequent
  • irregular
  • SHORT DISTANCE
  • WEAK
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14
Q

trigger of peristalsis

A

stretching (like for segmentation): local reflexes against stretching + circ and longit interaction

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15
Q

muscles behind bolus in peristalsis

A

circ contracts

longit relaxes

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16
Q

muscles ahead of bolus in peristalsis

A

circ relaxes

longit contracts

17
Q

peristalsis and segmentation: what is necessary for them to work

A

integrity of ENS

18
Q

modulation of peristalsis

A

ANS, hormones (vagus, Ach, PSS)

19
Q

ileocecal sphincter charact

A

high P, normally closed. opens when ileum distended. closes harder when cecum distended

20
Q

roles of colon

A

mixing and abso of water

21
Q

rectum fct

A

storage

22
Q

colon time to transit vs intestines

A 
intestines = 6 hours
colon = 50-60 hours
23
Q

freq of BER in colon

A

5-12 in ascending
8-12 TC
6-8 descending
17 sigmoid

24
Q

segmentation and peristalsis in colon: trigger

A

always there, governed by irregular BER

25
Q

3 reflexes for intestine and colon motility

A
  1. gastrocolic reflex and 2. gastroileal (when stomach full)

3. ileocolic: food in ileum = feel need to go to the bathroom

26
Q

interdigestive period charact

A

cyclic myoelectric activity. intervals of 90 min from stomach to ileum

27
Q

MMC (migrating myoelectric complex) phase 1 charact

A

60 min. no BER, no ERA.

28
Q

MMC phase 2

A

20 minutes. irregular ERA and contractions

29
Q

MMC phase 3

A

10 minutes regular spikes of contraction (ERA) ring moving down GI tract

30
Q

what initiates MMC

A

ENS. (CNS? ANS? gut peptides? too)

31
Q

what propagates MMC

A

ENS + MODULATION by ANS and gut peptides

32
Q

what interrupts MMC

A

meal intake

33
Q

MMC 2 fcts

A
  1. housekeeping and prevent bacterial overgrowth

2. non digestible particles clearance

34
Q

constipation on bristol stool chart

A

1-2

35
Q

IBS def

A

dx of exclusion: chronic abd pain and discomfort, high visceral sensitivity, constipation vs diarrhea dominant IBS

36
Q

bleeding in IBS

A

none

37
Q

3 possible causes of IBS

A
  • ICC disorder
  • serotonin pathway problem
  • post infectious IBS (surgery of H pylori)
38
Q

constipation IBS rx

A

anti cramps meds

39
Q

diarrhea IBS rx

A

rule out bacterial overgrowth. anxiety and psychological interventions

Bloc E - GI & Metabolism (58 decks)

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