Exam Two: Chemoattraction Flashcards
What is the name of the direct movement of Leukocytes called?
Chemoattraction
How is Chemoattraction mediated?
Mediated by Chemoattractants
What is essential in adhering a leukocyte to the blood vessel wall?
Adhesion Receptors
What is adhesion receptors used for?
Cell to Cell adhesion and Cell-matrix Adhesion
The movement of Leukocytes through the blood vessel wall into tissue is called either _____ or _____
Extravasation or diapedesis
List the Neutrophil Chemoattractants:
Interleukin-8
Leukotriene B4
Complement C5a
fMLP
What are the 4 classes of adhesion receptors?
- Selectins
- Addressins
- Integrins
- ICAMPs
What is an Integrin?
A Dimer with an alpha and beta chain that use ligands to do cell to cell binding or cell to matrix binding
What is the function of ICAMs?
Intracellular adhesion molecules
They function as binding partners with integrins in cell-cell adhesion
Selectins attach to what in weak cell-cell adhesion
attach to addresses which are carbohydrate chains
Which adhesion step is considered weak and which step is considered strong?
Weak binding = selectin to addressins
Strong binding = Integrin to ICAMs
Weak binding is also called?
Rolling
What is Leukocyte Adhesion Deficiency?
An inability for Neutrophils to bind to blood vessel walls, preventing chemoattraction
What is the cause of Leukocyte Adhesion Deficiency?
A defective gene that codes for B2 subunit of certain integrins
When do Naïve T cells differentiate
After they are exposed to an antigen in the lymph nodes
