Exam 3: COVID 19 and RNA

Question 1

ACE2 is a receptor for?

Answer 1

Spike Proteins

Question 2

TMPRSS2 is a protease that functions to?

Answer 2

Cleave the spike protein and activate it

Question 3

How does severe Pneumonia have the potential to develop in COVID?

Answer 3

As the virus replicates it passes to the lower airways

Question 4

A successful Adaptive immune response leads to what 2 things?

Answer 4

Viral clearance and recovery

Question 5

What happens when there is an excessive inflammatory response by macrophages and neutrophils?

Answer 5

The destruction of tissue and severe lung damage

Question 6

What is one disadvantage of using an RNA Vaccine?

Answer 6

They require ultra cold storage therefore you cant use them in widespread distribution in developing countries

Question 7

In RNA vaccine how are we able to inhibit the post-fusion actions of the proteins?

Answer 7

Through the use of Prolines, which are inflexible amino acids

Question 8

What are the 2 shapes that a SARS virus can make in its mechanism of invasion?

Answer 8

Pre and Post-fusion conformation

Question 9

What is the main difference between Conventional and Self-Amplifying RNA?

Answer 9

In conventional the cell uses its own mechanism to make viral antigens where as Replicase does that in self amplifying