Exam 4: Immunodeficiency\

Question 1

AIDS stands for

Answer 1

Acquired Immunodeficiency syndrome

Question 2

SCID stands for`

Answer 2

Severe Combined Immunodeficiency

Question 3

XLA stands for

Answer 3

X-linked gammaglobulemia

Question 4

What is a retrovirus?

Answer 4

RNA is used as the viruses’ genetic material and then uses it for reverse transcription to make DNA

Question 5

What is the main receptor for the HIV virus?

Answer 5

CD4

Question 6

What are the major genes that encode HIV genome?

Answer 6

1. Gag
2. Env
3. Pol

Question 7

What is the function of protease inhibitors?

Answer 7

Block the viral protease needed to cleave the poly-proteins into functional individual ones

Question 8

What is the function of the reverse transcriptase inhibitors?

Answer 8

Block the conversion of viral RNA to DNA

Question 9

SCID:

Answer 9

Severe Combine Immunodeficiency

Question 10

X-linked SCID aka bubble boy disease involves:

Answer 10

a defective subunit of cytokine receptors that makes T cells unresponsive to IL-2 and other cytokines

Question 11

Adenosine Deaminase deficiency involves:

Answer 11

an enzyme deficiency that leads to the accumulation of nucleotide metabolites that are toxic to T cells

Question 12

Transplant between members of the same species:

Answer 12

Allotransplant

Question 13

Total body Irradiation involves:

Answer 13

The destruction of bone marrow in the preparation of transplants

Question 14

X linked agammaglobulinemia is an example of what type of deficiency?

Answer 14

B cell development