[Exam 5] Chapter 67 - Mx of Patients with Cerebrovascular Disorders Flashcards
Cerebrovascular Disorders: What is this?
This is an umbrella term. Is functional abnormality of the CNS that occurs when the blood supply is disrupted
Cerebrovascular Disorders: What is the primary disorder seen here?
A stroke. Third leading cause of death in the United States
Cerebrovascular Disorders: Stroke is the leading cause of what
serious long-term disability in the United States
Cerebrovascular Disorders: The bigger the stroke, the bigger that what?
The bigger the infarction and the longer the rehab process wil be. Will have harder time getting back to ADLs.
Cerebrovascular Disorders: What is a ischemic stroke?
There has been some type of occlusion that results in hyperperfusion of the brain.
Cerebrovascular Disorders: How common are ischemic strokes?
they are about 85% of all strokes.
Cerebrovascular Disorders: What are hemorrhagic strokes?
This includes bleeding to the brain or subarachnoid space.
Cerebrovascular Disorders: What is the subarachnoid space?
Area between the pia matter and arachnoid mater.
Cerebrovascular Disorders: How common are hemorrhagic strokes?
Around 15% common. Not as common as ischemic strokes
Cerebrovascular Disorders - Prevention: What is one of the best things that we can do for strokes?
Prevention of them
Cerebrovascular Disorders - Prevention: What are some nonmodifiable risk factors?
Age (Older than 55), Male, African American
Cerebrovascular Disorders - Prevention: What are some modifiable risk factors?
Hypertension (Primary RF) Cardiovascular Disease Elevated Cholesterol or Hct Obesity Diabetes Oral Contraceptive use Smoking or Alcohol/Drug Use
Cerebrovascular Disorders - Prevention: Why are African Americans at larger risk?
They are at higher risk for hypertension, which is a big modifiable risk factor for strokes
Cerebrovascular Disorders - Prevention: What diet will be used?
DASH Diet. It sands for dietary appraoches to stop hypertension
Cerebrovascular Disorders - Prevention: What will be included in a DASH Diet?
High fruit, high veggie, low fat, low animal protein. Protein should come form plants
Cerebrovascular Disorders - Prevention: Protein from plants should come from where?
Nuts , seeds.
Cerebrovascular Disorders - Prevention: What do oral contraceptive use lead to?
Blood clots. If prone for blood clots, will be at higher risk for stroke with this
Stroke: Another term for this?
Brain attack.
Stroke: What is this sometimes called a brain attack?
You have a lack of blood flow to the brain tissue.
Stroke: What is a stroke?
Sudden loss of function resulting from a disruption of the blood supply to a part of the brain.
Stroke: What are the main causes of ischemic stroke?
Large Artery Thrombosis
Small Penetrating Artery Thrombosis
Cardiogenic Embolic
Crptogenic (No Known cause)
Stroke: Main presenting symptoms of ischemic stroke?
Numbness or weakness of the face, arm, leg, especially on one side of the body
Stroke: Functional recovery for ischemic stroke?
Usually plateaus at 6 months
Stroke: Causes of hemorrhagic stroke?
Intracerebral hemorrhage
Subarachnoid hemorrhage
Cerebral Aneurysm
Arteriovenous Malformation
Stroke: Main presenting symptoms of hemorrhagic stroke?
“Exploding Headache”
Decreased LOC
Stroke: Functional recovery for hemorrhagic stroke?
Slower, usually plateaus at about 18 months
Stroke: Simple definition of ischemic stroke?
Clot blocks blood flow
Stroke: Simple definition of hemorrhagic stroke?
Bleeding inside or around brain
Ischemic Stroke: Actual definition for this?
Disruption of the blood supply caused by an obstruction, usually a thrombus or embolism, that causes infarction of rbain tissue
Ischemic Stroke: What are the difefrent type of thromboses?
Large Artery Thrombosis
Small Penetrating Artery Thrombosis
Cardiogenic Embolism
Cryptogenic
Ischemic Stroke: What is a large artery Thrombotic Stroke
That is usually caused by plaque buildup in the large blood vessels
Ischemic Stroke: What si a small penetrating artery thrombosis?
Usually one or more smaller vessels. This is the most common. Also called Lacunar strokes. Named this because it creates a cavity in the brain tissue after infarction occurs
Ischemic Stroke: What is a cardiogenic embolism?
This is referring to a blood clot that came because the patient had afib.
Ischemic Stroke: What is a big problem with AFib?
People can have blood clots that cause strokes
Ischemic Stroke: What is a cryptogenic stroke?
Usually we don’t know what causes these. We cannot identify waht causees the lack of blood flow
Ischemic Stroke: What are other reasons for this?
Elicit drug use, coagulotherapy where they tend to clot more.
Migraines can cause this.
Ischemic Stroke - Patho: What happens ot the body once there is ischemia?
This leads to an energy failure. This means lack of oxygen in tissue leading to aerobic to anaerobic metabolism.
Ischemic Stroke - Patho: What happens in the body due to anaerobic metabolism?
You start to see an increase of lactic acid buildup. This leads to acidosis and ion imbalance.
Ischemic Stroke - Patho: After acidosis and ion imbalance occur, what occurs next in the body?
Depolarization leading to increase in glutamate and an increased in intracellular calcium.
Ischemic Stroke - Patho: What happens since there is an increase in intracellular calcium?
Cell membranes and proteins break down. Formation of free radicals and protein production decreased
This leads to cell injury and death
Ischemic Stroke - Patho: Why does calcium get released?
Once the neurons in the back start to get damaged from lack of blood flow
Ischemic Stroke - Patho: What is the complete patho of this?
Ischemia ->Energy Failure (Anaerobic, Lactic Acid) -> Acidosis/Ion Imabalance -> Depolarization (Increased Glutamate) and Intracellular Calcium Increased -> Cell membrane and probein break down, free radicals, and protein decreased -> Cell injury and death
Manifestations of Ischemic Stroke: Symptoms depend on what?
Location and size of the affected area
Manifestations of Ischemic Stroke: What are some signs of this?
Numbness or weakness of the face, arm , or leg, espeically on one side
Facial droop
Manifestations of Ischemic Stroke: Neurological changes?
Confusion or change in mental status
May have sudden, severe headache
Manifestations of Ischemic Stroke: How will their speech be?
Trouble speaking or understanding speech
Manifestations of Ischemic Stroke: Major difficulty with what?
Walking, dizziness, or loss or balance or coordination
Manifestations of Ischemic Stroke: What kind of disturbance may they have?
Perceptual Disturbances. Things aren’t making as much sense, maybe can’t see things as clearly as they are used to.
Stroke Terms: What is Hemiplegia?
Paralysis of the face, arm or legs. On the same side.
Remember that upper motor neurons cross in brain. Affected brain side will be opposite on motor
Stroke Terms: What is Hemiparesis
Weakness of the face, arm or legs on the same side
Stroke Terms: What is Dysarthria?
Difficulty in forming words
Stroke Terms: What is Expressive Aphasia
They are unable to form words. May be able to speak but not making sense.
Stroke Terms: What is Receptive Aphasia
They are unable to comprehend what is being said to them.
Stroke Terms: What is Hemianopsia
Patients are unaware of persons or object on the side of visual loss. Tend to neglect one side of the syndrome. May wash only right side of face or brush only right side of hair and forget about left.
Transient Ischemic Attack (TIA): What is this?
Temporary neurological deficit resulting from a temporary impairment of blood flow. Temporary motor loss.
Transient Ischemic Attack (TIA): How long does this last?
Less than an hour
Transient Ischemic Attack (TIA): Why is this significant?
Can be a warning of an impending stroke. 15% of strokes precipitated by this.
Transient Ischemic Attack (TIA): What is required after this?
Diagnostic workup required to treat and prevent irreversible deficits.
Transient Ischemic Attack (TIA): Workup for TIA or CVA will include what?
CT Scan initially. Should be done within 25 minutes of patients presenting to hospital.
EKG - Because we know AFib is a big cause of this, shows potential dysrhythmia.
Caratoid Ultrasound - Some determine some blockages.
CT Angiograph - Shows better look at vessels
MRI - Better look at tissues
Echocardiogram - Echocardio gram can get a better look at the valves, to see if clots forming here.
Preventive Treatment and Secondary Prevention: What is the most important thing to do?
Health Maintenance. This includes a healthy diet (DASH DIET), exercise, and the prevention and treatment of peridontal disease (can lead to valve problems, leading to blood clots, leading to stroke)
Preventive Treatment and Secondary Prevention: If patient has history of AFib, what will they be given
Anticoagulants. Couamdin/Warfarin used to be used and then monitor their INR to make sure they are having anticoagulant effect.
Preventive Treatment and Secondary Prevention: INR therapeutic range for Couamdin is what?
2-3 , very important to understand that
Preventive Treatment and Secondary Prevention: What newer anticoagulants may be used now?
Perderexa and Zoltero for patients in AFib.
Preventive Treatment and Secondary Prevention: What other type of medications may be used?
Antiplatelet Therapy
Statins
Antihypertensive
Preventive Treatment and Secondary Prevention: What kind of antiplatelets would be used?
Aspirin, Dipyridamole plus aspirin (Aggrenox) , Clopidogrel (Plaxis)
Preventive Treatment and Secondary Prevention: Aspirin can be used as what?
Antitcoagulant and antiplatelet
Preventive Treatment and Secondary Prevention: What is a first baselien treatment for antiplatelet?
Aspirin. IF at risk for stroke, clopidogren (plavix) used
Preventive Treatment and Secondary Prevention: Why are statins imporrant?
Help with cholesterol and plaque buildup
Preventive Treatment and Secondary Prevention: Why would antihypertensive medicatiosn be used?
Because if we know that they have high hypertension, we want to give them to help them control their blood pressure
Medical Mx of Acute Phase of Stroke: If a patient presents with this, what do you want ot do immediately?
Prompt diagnosis and treatment.
Diagnosis through CT to see if ischemic or hemorrhagic
Assessment of stroke using NIHSS Assessment tool
Thrombolytic Therapy
Medical Mx of Acute Phase of Stroke: What is the NIHSS assessment tool?
Basically, it goes through and scores patients on different areas. Looks at LOC (alert, unresponsive), gauze, facial drooping, check strength of extremities, see what their sensory is, are they able to articulate their words?
Goes through test to get their scores.
Medical Mx of Acute Phase of Stroke: Score ffor NIHSS assessment tool?
IT goes from 0-41. The higher the score, the more severe the stroke.
Medical Mx of Acute Phase of Stroke: NIHSS stands for what?
National Institute of Health Stroke Scale. Can be certified in this.
Medical Mx of Acute Phase of Stroke: Once they have been diagnosed and are having a iscshemic stroke, what is given first?
Thrombolytic Therapy.