[Exam 1] Chapter 58: Assessment and Management of Patients with Breast Disorders Flashcards
Ductal Carcinoma in Situ: What is this?
Characterized by proliferation of malignant cells inside the milk ducts without invasion to surrounding tissue. Does not metastasize, and woman does not die generally.
Ductal Carcinoma in Situ (DCIS): What can cause this to develop into invasive breast cancer?
If it is left untreated.
Ductal Carcinoma in Situ (DCIS): Frequently manifestated on a mammogram with what appearance?
Calcifications and considered breast cancer stage 0
Ductal Carcinoma in Situ (DCIS), Medical Mx: Takes what 3 things into account?
Assurance of accurate diagnosis, assessment of DCIS size and grade, and careful margin evaluation
Ductal Carcinoma in Situ (DCIS), Medical Mx: Grade III vs Grade I ?
Grade III tend to grow more quickly than grade 1 and look much more different than normal breast cells.
Ductal Carcinoma in Situ (DCIS), Medical Mx: Accurate grading of this is critical why?
Because high nuclear grade and presence of necrosis is highly predictive of the inability o achieve adequate margins or borders of healthy tissues around cancer.
Invasive Cancer, Infiltrating Ducal Carcinoma: What is this?
Most common, 80% of cases. Tumors arise from duct system and invade surrounding tissues. Often form a solid irregular mass in breast
Invasive Cancer, Infiltrating Lobular Carcinoma: What is this?
10-15%. Tumors arise from lubular epithelium and typically occur as an area of ill-defined thickening in the breast. Multicentric and bilateral.
Invasive Cancer, Medullary Carcinoma: What is this?
5%, more often in those <50 years. Tumors grow in a capsule inside a duct. Become large and may be mistaken for a fibroadenoma
Invasive Cancer, Mucinous Carcinoma: What is this?
3%. Those who are postmenopausal and >75 years. A mucin producer and tumor is slow growing.
Invasive Cancer, Tubular Ductal Carcinoma: What is this?
2%. Prognosis excellent. Micropapillary invasive ductal carcinoma is a rare type of aggressive ductal cancer charancterized by high rate of axillary node.
Invasive Cancer, Inflammatory Carcinoma: What is this?
Rare. aggressive type of breast cancer with unique symptoms./ Diffuse edema and erythema of skin (peau d’ orange, resmebling orange) are highlight signs of this
Invasive Cancer, Inflammatory Carcinoma: What causes this?
Maligant cels blocking lymph channels in skin. Mass may be present.
Invasive Cancer, Paget Disease: Symptoms incluide?
Scaly, erythematous, pruiritic lesion of the nipple. REpresents DCIS of the nipple but may have invasive co mponent.
Invasive Cancer, Paget Disease: What does it mean if no lump is felt?
This paired with DCIS without invasion shows favorable prognosis.
Invasive Cancer, Risk Factors: What may increase risk of development?
Combination of genetic, hormonal, and possibly environmental factors
Invasive Cancer, Risk Factors: What genes are responsible for this?
BRCA1 and BRCA2 are tumor suppressor genes. Mutations here on chromosome 17 responsible for majority of hereditary breast cancer.
Invasive Cancer, Risk Factors: What must be done if woman if BRCA positive?
Start screening, use mammography once a year than MRI 6 months after yearly mammography by 25.
Invasive Cancer, Protective Factors: What are some factors that may be proctective against development of breast cancer?
Breast feeding 1 year, moderate physical activity, and maintaining healthy body weight .
Breast Cancer Prevention Strategies In High Risk Patient, Long-Term Surveillance: This focuses on what?
Early detection. This means additional screening using MRI with yearly mammogram.
Breast Cancer Prevention Strategies In High Risk Patient, Chemoprevention: What is this?
Main modality that aims to prevent disease. Tamoxifen and Raloxifene are effective.
Breast Cancer Prevention Strategies In High Risk Patient, PRopylactic MAstectomy: What is this?
Procedure is a total mastectomy (removal of breast tissue) and is usually accompanied by immediate breast reconsutrction
Breast Cancer Prevention Strategies In High Risk Patient, PRopylactic MAstectomy: Who would use this?
Strong family history, diagnosis of LCIS, mutation in a BRCA gene, annd previous cancer in one breast.
Breast Cancer, CMs: What part of the breast is this found on
Upper outer quadrant, where most breast tissue located. Lesions nontender, fixed, and hard with irregular borders
Breast Cancer, CMs: Complaints include what?
About diffuse breast pain and tenderness with menstruation
Breast Cancer, Assessment/Diagnostic: Techniques to determine the diagnosis of breast cancer include?
Various types of biopsy. Tumor staging and additional prognostic factors
Breast Cancer, Staging: What does staging involve?
Classifying the cancer by the extent of the disease in the body. Based on where its invasive, size, and how many lymph nodes involved.
Breast Cancer, Staging: Most common system used to describe stages of cancer?
American Joiny Committee on Cancer TNM system.
Breast Cancer, Staging: What diagnostic tests may be used?
Chest X-Rays, CT Scan, MRI Scan, PET scan, bone scans, and blood work (CBC, comprehensive metabolic panel, and tumor markers)
Breast Cancer, Prognosis: Two of the most important factors are ?
Tumor size and whether it has spread to the lymph nodes under teh arm.
Breast Cancer, Prognosis: When will a carcinoma become clinically apparent?
When it doubles in sizes 30 times to become 1 cm or larger.
Breast Cancer, Prognosis: Most common route of regional spread is to where?
The axillary lymph nodes. Also internal mamary and supraclavicular nodes.
Breast Cancer, Prognosis: What other factors can help determine prognosis?
Excessive number of copies of certain genes or excessive amounts of their protein product.
Breast Cancer, Surgical Mx: Main goal of surgery?
To gain local control of disease.
Surgical Mx and Modified Radical Mastectomy: What is this?
Involves removal of breast tissue, including the nipple-areola complex. Portion of axillary lymph nodes also removed in axillary lymph node dissection (ALND(.
Surgical Mx and Modified Radical Mastectomy: What muscles are removed here?
PEctoralis major and pectoralis minor left intact.
Surgical Mx, Total Mastectomy: What does this involve?
Removal of breast and nipple-areola complex but does not include ALND.
Surgical Mx, Total Mastectomy: Who would get this surgery?
Those with noninvasive breast cancer which does not have a tendency to spread to the lymph nodes.
Surgical Mx, Total Mastectomy: What may also be performed for those with invasive breast cancer?
This along with sentinel lymph node biopsy
Surgical Mx, Breast Conversation Tx: What is this?
Goal is to excise the tumor in the breast completely and obtain clear margins which achieving acceptable cosmetic result. If noninvasive, lymph node removal not necessary.
Surgical Mx, Sentinel Lymph Node Biopsy: Why is SLNB preferred over ALND?
Less invasive. ALND is associated with potential morbidity including lymphedema, cellulitis, decreased arm mobility and sensory changes
Surgical Mx, Sentinel Lymph Node Biopsy: What is this lymph node?
This is the first node (or nodes) in the lymphatic basin that receives drainage from the primary tumor in the breast and identified by injecting a radioisotope or blue dye.
Surgical Mx, Sentinel Lymph Node Biopsy: What does the surgeon do in this procedure?
Uses a handheld probe to locate the sentinel lymph node, excises it, and sends it for pathologic analysis which is performed immediately
Surgical Mx, Sentinel Lymph Node Biopsy: What is done if this is positive?
Surgeon can proceed with an immediate ALND.
Surgical Mx, Sentinel Lymph Node Biopsy and Nursing Mx: How long do they stay in hospital?
If SLNB performed in conjunction with breast conservations, discharged same day.
If total mastectomy, usually stay overnight.
Surgical Mx, Sentinel Lymph Node Biopsy and Nursing Mx: What discoloration may they notice?
That because of radioisotope and blue dye, they may notice blue-green discoloration in urine or stool.
Patient Undergoing Surgery - Potential Complications:
Lymphedema, Hematoma, Infection
Patient Undergoing Surgery - Planning and Goals: Major goals may include what
increased knowledge about disease and treatment , reduction of anxiety, and improvement of decision-making abillity
Patient Undergoing Surgery - Preop, Providing Education: What surgery type causes a patient to remain overnight?
Breast conservation with ALND or total / modified radical mastectomy remain in hospital overnight.
Patient Undergoing Surgery - Preop, Providing Education: For those undergoing ALND, what will be inserted?
Surgical drains in mastectomy incision and in axilla.
Patient Undergoing Surgery - Preop, Providing Education: After ALND, they will have a decrease in what?
DEcreased arm and shoulder mobility and needs to be shown range-of-motion exercises.
Patient Undergoing Surgery - Preop, Reducing Fear/Anxiety: Fears can include what?
Fears of pain, mutilation, and loss of sexual attractiveness, and concern about inability to care for oneself.
Patient Undergoing Surgery - Postop, Relieving Pain/Discomfort: What patient would have the most pain after surgery
After having a modified radical mastectomy with immedicate reconstriction.
Patient Undergoing Surgery - Postop, Relieving Pain/Discomfort: Why may pain increase after first couple of days?
Because they begin to regain sensation around surgical site and become more active.
Patient Undergoing Surgery - Postop, Relieving Pain/Discomfort: Postop pain may be most common with which patient?
PAtients who have had axillary dissection and correlates with number of nodes removed.
Patient Undergoing Surgery - Postop, Managing Postop Sensations: Common sensations include what?
Tenderness, soreness, numbness, tightness and pulling. Occur on chest wall in axilla.
Patient Undergoing Surgery - Postop, Lymphedema: What is this?
Complication characterized by chronic swelling of extermity due to interrupted lymphatic circulation. Due to accumulation of protein-rich fluid.
Patient Undergoing Surgery - Postop, Lymphedema: What feelings may someone with thi shave?
painful swelling of arms as well as weakness, shoulder pain, and tinglign sesnation in arm and shoulder.
Patient Undergoing Surgery - Postop, Lymphedema: When does this happen?
If functioning lymphatic channels are inadequate to ensure a return flow of lymph fluid to general circulation.
Patient Undergoing Surgery - Postop, Lymphedema: What is transient edeema?
can be removed by prescribing exercising, elevating arm above heart and gentle muscle . pumping. Occurs after surgery
Patient Undergoing Surgery - Postop, Lymphedema: What is the patient taught after ALND?
Patient is taught hand and arm care to prevent injury or trauma to affected extremity, thus decreasing likelihood for development of lymphedema.
Patient Undergoing Surgery - Postop, Lymphedema: Treatment for this may consist of ?
A course of antibiotics agents if an infection is present. PT/OT may be necessary.
Patient Undergoing Surgery - Postop, Hematoma/Seroma Formation: What is hematoma and when can it occur?
Collection of blood inside a cavity, and may occur after either a mastectomy or breast conservation,
Patient Undergoing Surgery - Postop, Hematoma/Seroma Formation: Signs of Hematoma may include what?
Swelling, tightness, pain, and bruising of the skin. Surgeon should be notified immediately. Compression wrap may be applied for 12 hours.
Patient Undergoing Surgery - Postop, Hematoma/Seroma Formation: What is a seroma?
Collection of serous fluid that may accumulate under breast incision after mastectomy or breast conservation or in axilla.
Patient Undergoing Surgery - Postop, Hematoma/Seroma Formation: Signs of Seroma may include?
Swelling, heaviness, discomfort and a sloshing of fluid., May develop after drain removed.