[Exam 1] Chapter 58: Assessment and Management of Patients with Breast Disorders Flashcards
Ductal Carcinoma in Situ: What is this?
Characterized by proliferation of malignant cells inside the milk ducts without invasion to surrounding tissue. Does not metastasize, and woman does not die generally.
Ductal Carcinoma in Situ (DCIS): What can cause this to develop into invasive breast cancer?
If it is left untreated.
Ductal Carcinoma in Situ (DCIS): Frequently manifestated on a mammogram with what appearance?
Calcifications and considered breast cancer stage 0
Ductal Carcinoma in Situ (DCIS), Medical Mx: Takes what 3 things into account?
Assurance of accurate diagnosis, assessment of DCIS size and grade, and careful margin evaluation
Ductal Carcinoma in Situ (DCIS), Medical Mx: Grade III vs Grade I ?
Grade III tend to grow more quickly than grade 1 and look much more different than normal breast cells.
Ductal Carcinoma in Situ (DCIS), Medical Mx: Accurate grading of this is critical why?
Because high nuclear grade and presence of necrosis is highly predictive of the inability o achieve adequate margins or borders of healthy tissues around cancer.
Invasive Cancer, Infiltrating Ducal Carcinoma: What is this?
Most common, 80% of cases. Tumors arise from duct system and invade surrounding tissues. Often form a solid irregular mass in breast
Invasive Cancer, Infiltrating Lobular Carcinoma: What is this?
10-15%. Tumors arise from lubular epithelium and typically occur as an area of ill-defined thickening in the breast. Multicentric and bilateral.
Invasive Cancer, Medullary Carcinoma: What is this?
5%, more often in those <50 years. Tumors grow in a capsule inside a duct. Become large and may be mistaken for a fibroadenoma
Invasive Cancer, Mucinous Carcinoma: What is this?
3%. Those who are postmenopausal and >75 years. A mucin producer and tumor is slow growing.
Invasive Cancer, Tubular Ductal Carcinoma: What is this?
2%. Prognosis excellent. Micropapillary invasive ductal carcinoma is a rare type of aggressive ductal cancer charancterized by high rate of axillary node.
Invasive Cancer, Inflammatory Carcinoma: What is this?
Rare. aggressive type of breast cancer with unique symptoms./ Diffuse edema and erythema of skin (peau d’ orange, resmebling orange) are highlight signs of this
Invasive Cancer, Inflammatory Carcinoma: What causes this?
Maligant cels blocking lymph channels in skin. Mass may be present.
Invasive Cancer, Paget Disease: Symptoms incluide?
Scaly, erythematous, pruiritic lesion of the nipple. REpresents DCIS of the nipple but may have invasive co mponent.
Invasive Cancer, Paget Disease: What does it mean if no lump is felt?
This paired with DCIS without invasion shows favorable prognosis.
Invasive Cancer, Risk Factors: What may increase risk of development?
Combination of genetic, hormonal, and possibly environmental factors
Invasive Cancer, Risk Factors: What genes are responsible for this?
BRCA1 and BRCA2 are tumor suppressor genes. Mutations here on chromosome 17 responsible for majority of hereditary breast cancer.
Invasive Cancer, Risk Factors: What must be done if woman if BRCA positive?
Start screening, use mammography once a year than MRI 6 months after yearly mammography by 25.
Invasive Cancer, Protective Factors: What are some factors that may be proctective against development of breast cancer?
Breast feeding 1 year, moderate physical activity, and maintaining healthy body weight .
Breast Cancer Prevention Strategies In High Risk Patient, Long-Term Surveillance: This focuses on what?
Early detection. This means additional screening using MRI with yearly mammogram.
Breast Cancer Prevention Strategies In High Risk Patient, Chemoprevention: What is this?
Main modality that aims to prevent disease. Tamoxifen and Raloxifene are effective.
Breast Cancer Prevention Strategies In High Risk Patient, PRopylactic MAstectomy: What is this?
Procedure is a total mastectomy (removal of breast tissue) and is usually accompanied by immediate breast reconsutrction
Breast Cancer Prevention Strategies In High Risk Patient, PRopylactic MAstectomy: Who would use this?
Strong family history, diagnosis of LCIS, mutation in a BRCA gene, annd previous cancer in one breast.
Breast Cancer, CMs: What part of the breast is this found on
Upper outer quadrant, where most breast tissue located. Lesions nontender, fixed, and hard with irregular borders