[Exam 4] Chapter 38 - Assessment and Mx of Patients with Rheumatic Disorders, RA and SLE Flashcards
Diffuse Connective Tissue Disease: What is this?
Group of chronic disorders characterized by diffuse inflammation and degeneration in the connective tissue
Diffuse Connective Tissue Disease: What is the cause of this?
Cause is unknown but thought to have an immunologic basis
Diffuse Connective Tissue Disease: What are rheumatic arthritis disorders?
They are connective tissue disorders, autoimmune disorders. Bodies produces antibodies that attack their own healthy tissue.
Diffuse Connective Tissue Disease: Is there a cure?
There is no cure for this. We can only just treat the symptoms
Diffuse Connective Tissue Disease: Treatment will focus on what?
Controlling manifestations , and there will be periods of exacerbation’s and remissions.
Diffuse Connective Tissue Disease: What types of diseases doees this include?
RA, Systemic Lupus Erythematosus (SLE), Scleroderma, Polymyositis, and Polymtalgia rheumatica
Patho and Physical Signs of RA: This affects who more?
Females
Patho and Physical Signs of RA: What type of disease is this??
Autoimmune disease
Patho and Physical Signs of RA: This is thought to be associated with what?
Other disease processes, like atherosclerosis because it interferes with high density lipoproteins causing increase in bad cholesterol.
Patho and Physical Signs of RA: What is the Patho of this?
WBCs attack synovial tissue. Cause Synovial tissue to become inflamed.
Leads to systemic disease that can affect the whole body.
Patho and Physical Signs of RA: Initially patient will have what signs?
systemic joint pain and morning joint stiffness lasting longer than 1 hour. More than a little stiff after you get out of bed in morning.
Patho and Physical Signs of RA: This will have a normal course of what?
Exacerbations and remissions
Patho and Physical Signs of RA: What is the detailed patho hat occurs?
Presentation of antigen to T Cells
T,B Cells proliferate. Angiogensis in synovial lining.
Neutrophil accumulation in synovial fluid. Cell proliferation.
Synovitis, where there is degradation of cartilage by proteinase
Subchrondral bone erosion.
Patho and Physical Signs of RA: What signs occurs once T and B Cells proliferate?
Swelling in small joints, associated with pain, stiffness and fatigue
Patho and Physical Signs of RA: What signs occur with neutrophil accumulation in synovial fluid?
Warm, swollen effusions, pain and decreased motion with possible rheumatoid nodules
Patho and Physical Signs of RA: What signs occur with synovitis?
Increase in severity of physical signs and symptoms
Patho and Physical Signs of RA: What signs occur with subchrondral bone erosion?
Joint instability, contractures, decreased ROM
Extra Articular Features of RA: TO diagnose RA, what is tested?
Different antibodies, specifically this anti-CCP. This is really sensitive for RA.
If ESR is elevated
If CRP is elevated
IF WBCs are elevated
If Inflammatory makrers are elevated
Extra Articular Features of RA: What diagnostic can be done to determine degree of destruction?
X-RAY to determine destruction within joints,
Extra Articular Features of RA: What happens in Stage 1 of RA?
Body mistakenly attacks its own joint tissues
Extra Articular Features of RA: What happens in Stage 2 of RA?
Body makes the antibodies and the joints start swelling up
Extra Articular Features of RA: What occurs in Stage 3 of RA?
Joint becomes bent and deformed, fingers crooked, and can press on nerves to cause pain
Extra Articular Features of RA: What occurs in Stage 4 of RA?
If not treated, disease will progress to last stage, in which there’s no joint remaining and joint essentially fused
Extra Articular Features of RA: These are systemic manifestations , which include what?
Fever, Weight Loss
Fatigue/Anemia
Lymph Node Enlargement/Raynaud Phenomenon
Arteritis (inflammation of arteries)
Neuropathy
Pericardium
Sjorgen Syndrome
Extra Articular Features of RA: What is Raynaud Phenomenon?
Cold and stress induces vasopasms which causes episodes of distal blanching and cyanosis. Will see this in hands and toes. Loses blood flow to distal extremities
Extra Articular Features of RA: What is Sjorgen Syndrome?
Has to do with dry eyes, dry mouth, attacks glands that produce tears and end up with dry eyes.
Extra Articular Features of RA: What are the classic symtpoms seen with RA?
Joint pain, swelling, warmth, erythema.
Joints start to lose function
Extra Articular Features of RA: That symptoms of RA usually begins where and progresses where?
Begins in the hands, feet, wrists. As it progreses, will move into knees, shoulders, and larger joints