[Exam 1] Chapter 61: Management of Patients with Dermatologic Disorders Flashcards
Malignant Skin Tumors: Leading preventable cause of skin cancer?
Exposure to UV radiation, including sun and artifical UV rays
Malignant Skin Tumors: Over 99% of skin cancers include what?
Melanoma
Malignant Skin Tumors: The two most common types of nonmelanoma skin cancers are?
Basal Cell Carcinoma and Squamous Cell Carcinoma
Malignant Skin Tumors, BCC and SCC: Stats about BCC?
Rarely associated with morbidity and rarely causes men. 80% of men and 90% of women have this.
Malignant Skin Tumors, BCC and SCC: Stats about SCC?
Second most prevalent skin cancer.
Malignant Skin Tumors, BCC and SCC, CMs: Where does BCC appear?
On sun-exposed areas of body such as face,, neck, hands, and scalp.
Malignant Skin Tumors, BCC and SCC, CMs: How does a BCC begin as?
Small, waxy nodule with rolled, translucent, pearly borders. Undergoes central ulceration and sometimes crusting. Appears frequently on face.
Malignant Skin Tumors, BCC and SCC, CMs: Does BCC reoccur?
Rarely metastasizes, but recurrence is common.
Malignant Skin Tumors, BCC and SCC, CMs: A neglected BCC lesion can result in?
Loss of a nose, an ear, or a lip.
Malignant Skin Tumors, BCC and SCC, CMs: What is a SCC?
A malignant proliferation arising from the epidermis.
Malignant Skin Tumors, BCC and SCC, CMs: Precursor of SCC is usually what
actinic keratosis.
Malignant Skin Tumors, BCC and SCC, CMs: What does SCC arise from?
Appears on sun-damaged skin, but may arise from normal s kin or pre-existing lesions.
Malignant Skin Tumors, BCC and SCC, CMs: Why is SCC a greater concern than BCC?
Because it is invasive carcinoma, and metastasizing by blood or lymph system in 8% of cases
Malignant Skin Tumors, BCC and SCC, CMs: SCC appears how?
As a rough, thickened, scaly tumor that may be asymptomatic or may involve bleeding. Border may be wider. more inflammatory
Malignant Skin Tumors, BCC and SCC, CMs: What secondary thing can occur with SCCs?
Secondary infection.
Malignant Skin Tumors, BCC and SCC, CMs: Common sites for SCC?
Upper extremities and of the face. lower lip, ears, nose, and forehead.
Malignant Skin Tumors, BCC and SCC, Medical Mx: Treatment method depends on?
Tumor location, cell type, cosmetic desires of patient, and whether it is invasive.
Malignant Skin Tumors, BCC and SCC, Medical Mx: The management of BCC and SCC includes surgical excision, which may include?
Mohs micrographic surgery, electrosurgery, or cryosurgery.
Malignant Skin Tumors, BCC and SCC, Medical Mx: What are some alternatives for those not surgical candiates?
Radiation therapy, photodynamic therapy or topical chemotherapeutic creams
Malignant Skin Tumors, BCC and SCC, Surgical Mx: Best way to maintain cosmetic appearance?
Place the incision properly along natural skin tension lines and natural anatomic body lines.
Malignant Skin Tumors, BCC and SCC, Surgical Mx: What is done when tumor is large?
Reconstructive surgery with use of a skin flap or skin grafting. Incsion closed in layers to enhance cosmetic effect.
Malignant Skin Tumors, BCC and SCC, Surigal - Mohs Micrographic Surgery: What is this?
Most accurate surgical technique and best conserves normal tissue. Removes tumor layer by later.
Malignant Skin Tumors, BCC and SCC, Surigal - Mohs Micrographic Surgery: What doees the first layer excised include?
All evident tumor and a small margin or normal-appearing tissue. Specimen frozen and analyzed to see if tumor removed, if not, another layer shaved.
Malignant Skin Tumors, BCC and SCC, Surigal - Mohs Micrographic Surgery: Whar part of the body is this most useful on?
ARound the eyes, nose, upperlip. and auricular and periauricular areas
Malignant Skin Tumors, BCC and SCC, Surgical - Electrosurgery: what is this?
Destruction or removal of tissue by electrical energy. Current converted to heat, which then passes to tissue from cold electrode.
Malignant Skin Tumors, BCC and SCC, Surgical - Electrosurgery: This may eb preceded by what?
Curettage (excising the skin tumor by scraping its surface with a curette)
Malignant Skin Tumors, BCC and SCC, Surgical - Electrosurgery: After this, electrodesiccation is done why
to achieve homeostasis and destroy any viable malignant cells at the base of the wound or its edges. Useful for lesions smaller than 1-2 cm.
Malignant Skin Tumors, BCC and SCC, Surgical - Electrosurgery: This method takes advantage of what?
That utmor is softer than surrounding skin and can be outlined by a curette, which feels for the extent of the tumor. Usually repeated twice, and healing within 1 month
Malignant Skin Tumors, BCC and SCC, Surgical - Cryosurgery: How does this work
DEstroys tumor by deep-freezing the tissue. Needle inserted into skin and liquid nitrogen directed to center of tumor.
Malignant Skin Tumors, BCC and SCC, Surgical - Cryosurgery: What happens to tumor here?
Tissue is frozen, allowed to that, and then refrozen. Site thaws naturally and then becomes gelatinous and heals spontaneously.
Malignant Skin Tumors, BCC and SCC, Non-Surgical Alternatives: What are two options that can be done?
Local radiation therap or PDT
Malignant Skin Tumors, BCC and SCC, Non-Surgical Alternatives: What does PDT involve?
Application of 5-aminolevulinic acid to the lesion, which is followed by photoactivation with directed blue light for approximately 1 hour. Destroys neoplastic cells.
Malignant Skin Tumors, BCC and SCC, Non-Surgical Alternatives: Problem with PDT?
Skin may become red and blistered after any of these therapies
Malignant Skin Tumors, BCC and SCC, Nurse Mx: Patient is advised to watch for what?
Excessive bleeding and tight dressings that compromise circulation.
Malignant Skin Tumors, BCC and SCC, Nurse Mx: What is done after sutures are removed?
Emollient cream may be used to prevent dryness.
Malignant Skin Tumors, BCC and SCC, Nurse Mx: Follow-up exams should occur how often?
At regular intervals, usually every 3 months for a year. Should include palpation of adjacent lymph nodes.
Malignant Skin Tumors, Melanoma: Wht is this?
Nancerous neoplasm characterized by neoplastic melanocytes present in the epidermis and the dermis.
Malignant Skin Tumors, Melanoma: How deadly is this?
It is the most lethal
Malignant Skin Tumors, Melanoma, CMs: This may manifest as what>?
Change in the nevus or a new growth on the skin arising from cutaneous epidermal melanocytes.
Malignant Skin Tumors, Melanoma, CMs: Malignant melanoma looks how
dark, red, or blue colored, or a mix of any of these and irregular in shape.
Malignant Skin Tumors, Melanoma, CMs: What may this be associated with?
Itching, rapid growth, ulceration, and bleeding. Found mmore commonly in lower extremities.
Malignant Skin Tumors, Melanoma, CMs: Can occur in what forms?
Superficial Spreading of Melanoma (SSM)
Lentigo Maligna Melanoma (LMM)
Nodular Melanoma (NM)
Acral LEntiginous Melanoma (ALM)
Malignant Skin Tumors, Melanoma, CMs: In rare instances, melanomas may develop where?
In the uveal tract of the eye or from the mucosal lining of the GI or GU tract
Malignant Skin Tumors, Melanoma, CMs: Spread in what two growth phases?
Radial and vertical
Malignant Skin Tumors, Melanoma, CMs: What occurs during the first growht phase ,the radial phase?
Cutaneous melanomas tend to spread radially within the layer of the epidermis. Is most amenable to treatment
Malignant Skin Tumors, Melanoma, CMs: What occurs during the second growth phase, the vertical phase?
Characterized by vertical tumor growth into the dermal layer and eventual metastasis.
Malignant Skin Tumors, Melanoma, Assess/Diagnostic: What confirms the diagnosis of melanoma?
Biopsy results
Malignant Skin Tumors, Melanoma, Assess/Diagnostic: Excisional biopsy provides information on what
type, level of invasion, adn thickness of lesion. Includes a 1-2 cm margin of normal tissue.
Malignant Skin Tumors, Melanoma, Assess/Diagnostic: When should incisional biopsy be performed?
When suspicious lesion is too large to be removed safely without extensive scarring.
Malignant Skin Tumors, Melanoma, Assess/Diagnostic: What should a thorough history and physicl exam include?
A meticulous skin exam and palpation of regional lymph nodes that drain the lesional area.
Malignant Skin Tumors, Melanoma, Assess/Diagnostic: What is usually performed after diagnosis of melanoma is confirmed?
Chest X-Ray, CBC, complete chemistry panel with creatinine, liver function tests, and lactate dehydrogenase (LDH) performed
Malignant Skin Tumors, Melanoma, Assess/Diagnostic: How will LDH levels be here?
Elevated in presence of metastatic disease.
Malignant Skin Tumors, Melanoma, Assess/Diagnostic: Depending on results, what diagnostic tests can be performed?
MRI of brain, CT scans of chest, abdomen, or pelvivs, and PET scan of the lymphatics.
Malignant Skin Tumors, Melanoma, Assess/Diagnostic: Staging of tumors follows what system?
TNM
Malignant Skin Tumors, Melanoma, Medical Mx: What is the treatment of choice for small, superficial lesions?
Surgical excision
Malignant Skin Tumors, Melanoma, Medical Mx: Deeper lesiosn require what?
Wide, local excision where skin grafting may be necessary
Malignant Skin Tumors, Melanoma, Medical Mx: Sentinel lymph node biopsy performed why
to examine the nodes nearest the tumor and to spare the patient the long-term sequelae of extensive removal of lymph nodes.
Malignant Skin Tumors, Melanoma, Medical Mx: What genetic mutation do most people have which helps in guiidng targeted therapy?
BRAF
Malignant Skin Tumors, Melanoma, Medical Mx: Patients with Stage II/III considered at risk for relapse are typically prescribed what?
High-dose interferon alpha-2 IV for 4 weeks, followed by subcutaneous dosing for an additional 48 weeks. Helps with decreased rates of relapse.
Care of Pt With Melanoma, Assess: The patient is asked specifially about what
pruritus (itching), tenderness, and pain which are not features of benign nevus.
Care of Pt With Melanoma, Assess: Moles can be assessed by using ABCDE, which stand for what
A: Asymmetry B: Irregular Broder C: Variegated Color D: Diameter E: Evolving
Care of Pt With Melanoma, Assess: Common sites of melanomas include
skin of the back, legs, between toes, and on the feet, face, scalp, fingernails and back of hands.
Care of Pt With Melanoma, Assess: Potential problems from this?
Metastasis
Care of Pt With Melanoma, Reducing Anxiety: Support includes what
encouargign the patient to express anxieities and feelings about serousness of neoplasm
Care of Pt With Melanoma, Monitoring/Managing Complications: What would cause a greater likelihood ofmetastasis?
A deeper and thicker melanoma
Care of Pt With Melanoma, Monitoring/Managing Complications: Signs of metastasis may include?
Lung (difficult breathing, SOB)
Bone (Pain, decreased mobility, fractures)
Liver (change in liver enzyme levels, pain, jaundice)