[Exam 4] Chapter 14 - Shock and Multisystem Failure Flashcards
Shock: What is this?
Life-threatening condition related to inadequate tissue perfusion.
Shock: Inadequate blood flow results in what changes to occur in body?
Poor delivery of oxygen and nutrients
Cellular Hypoxia
Cell death that progresses to organ dysfunction and eventually death
Shock: What do you need for adequate flow to tissues?
Effective Cardiac Pump (Heart can effectively pump blood to rest of organs)
Adequate Vasculature/Circulatory System
Sufficient Blood Volume
Shock: What should we think about shock when we hear this?
That there is not enough tissue perfusion happening in these patients.
Shock: How does the body respond to shock?
By activation of the inflammatory response. Will then have hyperperfusion of tissues, hypermetabolism due to increased need for energy since tissues aren’t being perfused.
Shock - Patho, Cellular Changes: What happens when inflammatory response kicks in?
You have increased permeability which leads to leaky vessels. Electrolytes and fluids go in-and-out.
Mitochondria will be damaged and you will have cell death
Shock - Patho, Cellular Changes: How will the cell look?
You can have cellular edema. Fluids are leaking out. Will also have mitochondrial damage due to swelling.
Shock - Patho, Cellular Changes: What changes occur electrolyte wise?
You will have efflux of potassium leaving
Large influx of Sodium and H2O coming in. flooding membranes
Shock - Patho, Cellular Changes: The cell will change from aerobic metabolism to what?
anaerobic metabolism.
Shock - Patho, Cellular Changes: What usually occurs in aerobic metabolism?
That is how we normally function. Glucose/oxygen goes into cell and outputs CO2 and Water to produce a lot of energy
Shock - Patho, Cellular Changes: How does anaerobic work?
This is only using glucose. Only glucose goes into cell and lactic acid gets kicked out. This releases only a small amount of energy and creates an oxygen debt to break down all that lactic acid.
Shock - Patho, Cellular Changes: What is the important thing to realize for shock on cellular level?
When patient goes into shock, they have inadequate tissue perfusion so no oxygen.
Not enough oxygen to do aerobic metabolism so they’lll switch to anaerobic. Causes buildup of lactic acid.
Shock - Patho, Cellular Changes: Activation of stress response causes what changes to occur with energy levels?
Increased glucose levels , decreased insulin and the body becomes more insulin resistance. Cannot utilize the glucose. Depletes glycogen reserves and body gets energy from protein.
Shock - Patho, Cellular Changes: what changes occur with clotting cascade
You will start to see small clots which can lead to decreased cellular perfusion because of mini-clots building up here.
Shock - Patho, Cellular Changes: Big cellular changes relate to what?
Increased permeability , activates of stress response, and clotting cascade
Shock - Patho, Vascular Response: During this response , you have the release of what?
Cytokines.
Shock - Patho, Vascular Response: The release of cytokines does what to body?
Stimulates vasodilation or vasoconstriction . This is why vasodilation occurs with patients.
Shock - Patho, BP Regulation: When looking at this, what should we be looking at?
Mean Arterial Pressure (MAP) . Tissue perfusion and organ perfusion depend on this .
Shock - Patho, BP Regulation: What is MAP?
Cardiac Output x Peripheral Resistance.
Shock - Patho, BP Regulation: What level should this be at?
MAP should be over 65 to maintain adequate tissue perfusion.
Shock - Patho, BP Regulation: How does RAAS play a role here?
If kidneys not getting perfused, RAAS will be kicked in. Will have Angiotensin I -> Anngiotensin II whick causes vasoconstriction
Also have ADH kicked in that causes kidneys to retain water to help increased blood volume and blood pressure in patients.
Stages of Shock: What are the stages of shock?
Compensatory
Progressive
Irreversible
Stages of Shock - Compensatory: What occurs here?
The body is trying to compensate for what is going on
Stages of Shock - Compensatory: Blood pressure here?
Will usually remain within normal limits
Stages of Shock - Compensatory: What changes occur here?
Release of biochemical mediators, cytokines, and start to cause vasoconstriction increasing HR and increased contractility. Blood is shunted to vital organs like lungs, brains. Body is compensating.
Stages of Shock - Progressive: What stage is this?
The 2nd stage of shock
Stages of Shock - Progressive: What blood pressure changes occur?
MAP below normal limits.
Systolic < 90.
If hypertensive, will have a drop of 40 mm of mercury from baseline. If 160/90, will drop to 120/70
Stages of Shock - Progressive: What changes occur in rest of body?
Mental status changes in patient.
Overworked heart doesn’t beat at optimal level
Will start to see increased capillary permeability from inflammatory response being initiated. Coagulation cascade also activated, leading to microemboli.
Stages of Shock - Progressive: How does this progress?
This just continues to progress and get worse.
Stages of Shock - Irreversible: How does this progress?
The patients are not going to recover from this stage of shock
Organs so damaged that they don’t respond to treatment.
Stages of Shock - Patho: What initially happens to the body when there is an initial insult leading to shock state?
Decrease in tissue perfusion and oxygenation. Leading ot activation of homeostatic response
Stages of Shock - Patho: What homeostatic responses occur?
Increase sympathetic response (Increase HR, BP, Cardiac Contractility = Increased CO)
Increase in RAAS
Increased in RR to increase oxygen saturation
Increase in catecholamines and cortisol to provide increased glucose for metabolism
Types of Shock: What are the different types?
Cardiogenic
Circulatory
Hypovolemic
Neurogenic
Types of Shock: Cardiogenic shock is a result of what?
When something happens to the heart.
Types of Shock: Circulatory shock is a result of what
This is Broad statement for shock. This is sometimes interhcanged with distributive.
Types of Shock: Regardless of the type of shock, what is imperative to do?
Must have early identification and timely treatment
Types of Shock: Shock needs to be identified early why?
So that we can identify treatments. The longer it takes to identify shock, the longer it will take to identify positive outcomes.
Types of Shock: How can you identify and treat underlying cause?
If hypovolemic, give them some fluids. Sequence of events for shock will vary but management and care can be done for all types.
Types of Shock: If patient is septic, what can we give them?
Antibiotics
General Shock Mx: First off, you want to support what?
The respiratory system. Will be on either supplemental O2 through nasal cannula but may be mechanically ventilated as they progress to provide optimal oxygenation
General Shock Mx: Fluid replacement is given why?
To restore intravascular volume. Different types of fluids can be given
General Shock Mx: What are some fluids can be given for shock?
Normal Saline
Lactated Ringers
because patient is losing fluid to intersittial space because of capillary permeability.
General Shock Mx: Fluids are adminsitered why?
Will be given early in shock. Administered to improve cardiac and tissue oxygenation.
General Shock Mx: Why is Lactated Ringers given more often than normal saline?
Because it has a lactate ion in it. It contains bicarb and will help buffer.
General Shock Mx: What is 0.9% NS usually used for?
To expand volume, dilute medications and keep vein wide open
General Shock Mx: What is Lactated Ringers usually used for?
Fluid resuscitation
General Shock Mx: What do 0.9% NS and Lactated Ringers have in commmon?
they are both isotonic and have ethe same osmolarity as body fluid
General Shock Mx: What is D5W usually used for?
Usually isotonic but once in body, metabolizes glucose and becomes hypotonic
General Shock Mx: What is D5 1/2 NS and D5NS usually used for?
USed for Na and Volume replacement. Go slow, monitor BP, pulse rate, and quality of lung sounds as well is serum NA and output.
General Shock Mx: Who would you not give D5W to?
Infants or head injury patients. Will cause cerebral edema
General Shock Mx: Why must you be careful with giving patients too much fluid?
Can throw them into fluid volume overload, causing pulmonary edema and abdominal compartment syndrome.
General Shock Mx: What are colloid solutions?
They are similar to plasma and plasma proteins. Molecules too large to pass through capillary membrane.
General Shock Mx: What kind of solutions are colloid?
This includes albumin and plasmonate. These are volume expanders.
General Shock Mx: Wh are crystalloid and colloid solutios not used?
Because they are quite pricey. To get extra volume, can give NS or LR.
General Shock Mx: Complications of fluid administrtion include what
cardiovascular overload or pulmonary edema.
General Shock Mx: How do you know if fluid resuscition is successful?
Can look at output. If adequate urine output produced, thats how you know.
If CVP (2-6) placed, can tell. If it is increased, then you know that they are maintaining fluid volume status
General Shock Mx: How do you know if the patients are becoming fluid overloaded?
Looking and listening for lung sounds. Were they clear to begin with and now you hear crackles?If so, may need to back off on fluid.
General Shock Mx: Patients will be sick, so they may have central line or arterial line or pulmonary artery catheter. What must you watch for with these patients?
CATBI. A central line associated bloodstream infection. Make sure dressings are inclusive. and intact.
General Shock Mx: Patients will need nutritional support why?
To address the metabolic requirements.
General Shock Mx: Patient will be on vasoactive medication why?
Will also see them on vasoactive medication to restore vasomotor tone and improve cardiac function.
Shock Mx - Vasoactive Med Therapy: When you think of vasoactive meds, what can they cause?
Constriction of those vessels , causing them to clamp down
Or they can also vasodilate.
Shock Mx - Vasoactive Med Therapy: How will these meds act for someone in shock??
They will always be vasoconsricting because we need to get the blood pressure up.
Shock Mx - Vasoactive Med Therapy: What changes will this cause inside of the body?
Increase myocardial contractility strength
Regulate HR
Reduce myocardial resistance
Initiate vasoconstriction
Shock Mx - Vasoactive Med Therapy: How will the medications be selected?
By their action.
Shock Mx - Vasoactive Med Therapy: What are the different types of medications available?
Inotropes - Help with squeeze
Vasodilators - They Vasodilate
Vasopressors
Shock Mx - Vasoactive Med Therapy: What is important for us to do as nurses when someone is on this?
Monitor VS’s. Will be on cardiac monitor and will have arterial pressure line to give continuous blood pressure readings.
Shock Mx - Vasoactive Med Therapy: Why would vasopressors also be titrated?
To maintain a certain blood pressure. They will be titrated to keep the MAP > 65.
Shock Mx - Vasoactive Med Therapy: What precaution must you take for someone on norepinephrine?
You never want to just shut it off. You want to titrate slowly to make sure you give patient time to compensate to get off of medication.
Shock Mx - Vasoactive Med Therapy: What are some examples of inotropic agents?
Dobutamine (Dobutrex)
Dopamine (Intropin)
Epinephrine (Adrenalin)
Milrinone (Primacor)
Shock Mx - Vasoactive Med Therapy: What is the desired action of shock?
Improve contractility, increase stroke volume, increase cardiac output
Shock Mx - Vasoactive Med Therapy: Disadvantage of inotropic agents?
Increase oxygen demand of the heart
Shock Mx - Vasoactive Med Therapy: Examples of vasodilators?
Nitroglycerin (Tridil)
Nitroprusside (Nipride)