Exam 4 - Thyroid Flashcards
the thyroid gland is very ___
vascular
5 x’s the blood flow to the liver
Thyroid hormones
T3, T4, calcitonin
where is the parathyroid?
inside the thyroid gland
TSH comes from the ___ ___ ___
anterior pituitary gland
what controls the release of T3, T4
TSH
when is calcitonin released?
high plasma calcium levels
increases calcium deposit in bone
thyroid hormone production within normal limits
euthyroid
thyroid is controlled by what feedback system?
negative
low T3, T4 will cause an increase in
TSH
what is the issue with primary thyroid disorder
thyroid is the issue
no longer listening to the anterior pituitary gland
what is the issue with secondary thyroid disorder
anterior pituitary gland
no longer listening to the hypothalamus
what is the issue with central thyroid disorder
hypotalamus
childhood thyroid disoder
cretinism
neonatal hypothyroidism is tested when?
24-48 hours after birth
r/t low iodine, mental retardation
most common condition r/t hyperthyroidism
Grave’s disease
excess output of thyroid hormone
thyrotoxicosis
hyperthyroidism s/sx
nervousness rapid pulse heat intolerance tremors skin flushed, warm, soft and moist exophthalmos increased appetite weight loss elevated SBP cardiac dysrhythmias
thyrotoxicosis puts the body in which state?
hyper-metabolic state
most sever hyperthyroid disorder
thyroid storm
protruding or bulging eyes as a result of impaired venous drainage from the orbit
exophthalmos
exophthalmos is only seen in ___ disease
Grave’s
early stage of hyperthyroidism may only have which 2 s/sx
nervousness
weight loss
meds to tx hyperthyroidism
propylthiouracil (PTU) + methimazole
Na, K iodine solutions
dexamethasone
beta-blockers (propranolol
purpose of PTU + methimazole
Tapazole
inhibit/block synthesis of thyroid hormones
how long does it take to see improvement with PTU + methimazole
1-2 weeks but can take 4-8 weeks
side effects/labs of PTU + methimazole
agranulocytosis
**low WBC, neutrophil, eosinophil
thrombocytopenia
hepatoxicity
how often is PTU taken?
who can take it?
TID
pregnant women in their 1st trimester
how often is Tapazole taken
daily
propranolol is contraindicated in who?
asthma
severe heart disease
cause of thyroid storm
stressors such as infection, trauma, surgery
thyroid storm s/sx
severe tachycardia heart failure hyperthermia (up to 105.3) agitation seizures N/V/D delirium coma
pts who have a ___ are in danger of having a thyroid storm
thyroidectomy
hyperthyroidism TSH and T4 level will be ___
elevated
best indicator of hyperthyroidism
free thyroxine (T4)
hyperthyroidism treatment of choice for most nonpregnant adults
radioactive iodine therapy (RAI)