EXAM 4- Skeletal muscle, bone, joint disorder Flashcards
1
Q
Rheumatoid arthritis (RA)
A
an autoimmune disorder that causes inflammatory changes in the connective tissue.
2
Q
Three classification drugs used to treat RA
A
- NSAIDS
- corticosteroids
- disease-modifying antirheumatic drugs (DMARDs)
3
Q
DMARDs Action
A
Have properties that produce immunosuppression, which in turn decreases the body’s autoimmune response.
4
Q
uses of DMARDs
A
- Rheumatoid arthritis
- Crohn’s disease
- Fibromyalgia
5
Q
ex of DMARD
A
- adalimumab (Humira)
- infliximab (Remicade)
- methotrexate (MTX)
- sulfasalazine (Azulfidine)
- abatacept (Orencia)
6
Q
adverse reactions of DMARD
A
- Nausea
- Stomatitis
- Alopecia (hair loss)
- GI upset
- Mild pancytopenia
- Injection site irritation
7
Q
contraindications of DMARD
A
- Hypersensitivity
- Renal insufficiency
- Liver disease
- Alcohol abuse
- Pancytopenia
- Heart failure
8
Q
Paget’s disease
A
bone growth weakening
9
Q
osteoporosis
A
loss of bone mass
10
Q
biphosphonates action
A
- inhibits all bone reabsorption (increases bone mineral density)
- ->This action REVERSES the progression of osteoporosis
11
Q
uses of biphosphonates
A
- Osteoporosis in postmenopausal women and men (caused by glucocorticoid use)
- Hypercalcemia related to malignant diseases and tumors
- Paget’s disease
12
Q
adverse reactions of biphosphonates
A
- Nausea, diarrhea
- Increased or recurrent bone pain
- Headache
- Dyspepsia (GI discomfort), acid regurgitation, dysphagia
- Abdominal pain
13
Q
contraindications of biphosphonate
A
- Hypocalcemia
- Delayed esophageal emptying
- Renal impairment
14
Q
skeletal muscle relaxant actions
A
Do not directly relax skeletal muscles, but their ability to relieve acute painful musculoskeletal conditions may be due to the sedative action.
15
Q
ex of skeletal muscle relaxants
A
- baclofen (Lioresal)
- carisoprodol (Soma)
- methocarbamol (Robaxin)
- tizanidine (Zanaflex)
